Josephine C.
Adams , Ph.D.[Associated Requests/Data] Staff,
Dept of Cell Biology @ Lerner Research Instiute, The Cleveland Clinic Foundataion, Ohio (USA) Subgroup(s): [Glycans in cancer biology, Structural glycobiology]
Research interests: This laboratory focuses on the molecular mechanisms of cell -extracellular matrix interactions. One project is to examine possible carbohydrate-based interactions of the conserved extracellular glycoprotein, thrombospondin-1, with cell-surfaces and extracellular matrix components.
Mavis
Agbandje-McKenna , Ph.D.[Associated Requests/Data] Associate Professor,
Dept. of Biochem. and Molecular Biology @ University of Florida, Center for Structural Biology, The McKnight Brain Institute, Gainesville, FL (USA) Subgroup(s): [Structural glycobiology, Glycans in cancer biology, Glycans in host-microbe interactions]
Research interests: This laboratory focuses on structure-function correlations for virus capsids, particularly, ssDNA capsids, with a T=1 icosahedral symmetry. The goal is to develop strategies for the treatments of diseases of that afflict plants, animals and humans in the form assembly disrupters, vaccines, and antigen and gene delivery vectors.
Rafi
Ahmed , Ph.D. Professor,
Department of Microbiology and Immunology @ Emory University School of Medicine, Atlanta, GA (USA) Subgroup(s): [To be Assigned]
Research interests: The immune system can remember, sometimes for a lifetime, the identity of a pathogen. The primary research interest of this laboratory is to understand the mechanisms by which long-term immunity is maintained and to use this information to develop vaccines that will confer long-term protective immunity.
Tomoya O.
Akama , Ph.D. Research Assistant Professor,
Burnham Institute for Medical Research, La Jolla, CA (USA) Subgroup(s): [Glycans in development and physiology
, Glycans in cancer biology]
Research interests: This laboratory focuses on investigating the biosynthetic pathway and biological function of keratan sulfate glycosaminoglycan in the cornea
Brian J.
Akerley , Ph.D. Assistant Professor,
ept. of Molecular Genetics and Microbiology @ Unversity of Massachusetts Medical School, Worcester, MA (USA) Subgroup(s): [Glycans in immune recognition and function
, Glycans in host-microbe interactions]
Research interests: This laboratory focuses on the Haemophilus influenza relationship between physiological adaptations to the host environment and the coordinated production of bacterial cell-surface structures.
Steven C.
Almo , Ph.D.[Associated Requests/Data] Professor,
Dept of Biochemistry @ Albert Einstein College of Medicine, Bronx, NY (USA) Subgroup(s): [To be Assigned]
Research interests: This laboratory focuses in the structural and biochemical analysis of the cell surface receptors and ligands responsible for T cell costimulation
Hans-Peter
Altevogt , Ph.D.[Associated Requests/Data] Professor,
Cell Adhesion and Metastasis @ German Cancer Research Center, DKFZ, Heidelberg (Germany) Subgroup(s): [Glycans in cancer biology]
Research interests: This laboratory is focusing on the functional role of glycans on the molecules of interest and the CD24 and L1 (CD171) interaction with selectins and other glycan binding proteins
Jörg
Andrä , Ph.D.[Associated Requests/Data] Project Leader,
Department of Biotechnology @ Hamburg University of Applied Sciences (Germany) Subgroup(s): [Glycans in cancer biology, Glycans in host-microbe interactions]
Research interests: This laboratory focuses on membrane-interacting peptides of the innate immune system (antimicrobial/host defence peptides). We study their mode of action with model membranes and living cells and we use this peptides as lead structures for novel antibacterial, anti-spesis, and anti-cancer agents.
Pablo
Argueso , Ph.D.[Associated Requests/Data] Investigator-Instructor,
Dept of Ophthalmology @ The Schepens Eye Research Institute, Harvard Medical School, Boston, MA (USA) Subgroup(s): [Glycans in host-microbe interactions, Glycomics and glycoinformatics, Glycan synthesis and microarrays
]
Research interests: The major focus of Dr. Argueso's research is to characterize the carbohydrate portion of the different mucins expressed by the ocular surface epithelia as well as the enzymes involved with their synthesis, and to determine whether the alteration of mucin glycosylation is associated with ocular surface disease.
Carlos
Arias , null[Associated Requests/Data] Professor,
Instituto de Biotecnologia, Universidad Nacional Autonoma de Mexico Subgroup(s): [To be Assigned]
Research interests: In conjunction with Pavel Isa, study rotaviruses
Kiyoshi
Ariizumi , Ph.D.[Associated Requests/Data] Associate Professor,
Dept of Dermatology @ The University of Texas Southwestern Medical Center at Dallas, TX (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory is focusing in the interaction of glycans with DC-HIL/gpnmb/protein receptors on leukocytes, particularly in antigen presenting cells.
Raffi
Aroian , Ph,D.[Associated Requests/Data] Professor,
University of California, San Diego Subgroup(s): [To be Assigned]
Research interests: Crystal proteins made by Bacillus thuringiensis and their interaction with carbohydrate chains on glycolipids, specifically how the protein interacts with its carbohydrate receptor and how this interaction alters the protein prior to insertion into the membrane (as a pore-forming protein).
Aravind
Asokan , Ph.D. [Associated Requests/Data] Research Associate,
Gene Therapy Center @ University of North Carolina, Chapel Hill, NC (USA) Subgroup(s): [Structural glycobiology, Glycans in host-microbe interactions]
Research interests: One of the specific areas of focus in this laboratory involves understanding molecular aspects of AAV capsid-glycan interactions and the impact of such on biodistribution and tissue tropisms of AAV in animal models in vivo.
Peter
Balogh , M.D., Ph.D.[Associated Requests/Data] Associate Professor,
Department of Immunology and Biotechnology @ University of PÈcs (Hungary) Subgroup(s): [Glycans in development and physiology
, Glycans in immune recognition and function
]
Research interests: This laboratory focuses on the communication pathways occurring between various stromal components (i. e. fibroblasts, follicular dendritic cells, endothelium and marginal zone macrophages) during the ontogeny of the spleen, and their role in the maintenance of various forms of B-cell responses in mice.
Joseph T.
Barbieri , Ph.D.[Associated Requests/Data] Professor,
Microbiology and Molecular Genetics @ Medical College of Wisconsin, WI (USA) Subgroup(s): [Glycan synthesis and microarrays
]
Research interests: This laboratory is focusing on the understanding how the botulinum neurotoxins (BoNTs) utilize gangliosides as co-receptors for entry into neurons.
Nora A.
Barrett , M.D. Scientist,
Brigham and Womens Hospital / Harvard University, Boston, MA (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory is focusing on the mouse models of allergic airway inflammation and the dendritic cell pattern recognition receptors activated in response to allergen extracts from house dust mite and mold.
Linda
Baum , M.D., Ph.D.[Associated Requests/Data] Professor,
Department of Pathology and Laboratory Medicine @ UCLA, Los Angeles, CA (USA) Subgroup(s): [Glycans in cancer biology, Glycans in immune recognition and function
]
Research interests: This lab investigates how protein-carbohydrate interactions affect cell fate in the immune system. The specific focus is on the mechanism of galectin-1 mediated death of T lymphocytes, and the role of galectin-1 in immune development, lymphocyte homeostasis, response to pathogens, autoimmunity and tumor cell evasion of the immune response.
Andreas J.
Baumler , Ph.D[Associated Requests/Data] Professor,
Department of Medical Microbiology and Immunology @ University of California at Davis, CA (USA) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory focuses on the role of fimbrial adhesins in Salmonella pathogenesis and on the host response to infection.
Eric
Bennett , Ph.D.[Associated Requests/Data] Associate Professor,
Department of Physiology & Biophysics @ University of South Florida College of Medicine, Tampa, FL (USA) Subgroup(s): [Structural glycobiology]
Research interests: We study the role of glycosylation in ion channel function. Specfically, we are focusing on how ion channel glycosylation modulates, controls, and impacts cardiac, skeletal muscle, and neuronal electrical activity.
Marshall
Bern , Ph.D. Principal Scientist,
Computing Sciences Laboratory @ Palo Alto Research Center, Palo Alto, CA (USA) Subgroup(s): [Glycomics and glycoinformatics]
Research interests: This laboratory is focus on developing algorithms for analyzing high-throughput biological data.
Michael
Betenbaugh , Ph.D. Professor,
Department of Chemical and Biomolecular Engineer @ Johns Hopkins University, Baltimore, MD (USA) Subgroup(s): [To be Assigned]
Research interests: This laboratory is focusing on bioinformatics techniques for incorporating mass spectroscopy data and gene expression profiles into mathematical models of glycosylational processing.
Carole A.
Bewley , Ph.D.[Associated Requests/Data] Principal Investigator,
Laboratory of Bioorganic Chemistry @ NIDDK, National Institutes of Health, Bethesda, MD (USA) Subgroup(s): [Glycans in host-microbe interactions, Structural glycobiology]
Research interests: This laboratory ongoing projects include identification of novel carbohydrate binding proteins that potently block viral entry (especially HIV-1) through carbohydrate-mediated interactions, complete characterization of affinity and specificity, and elucidation of the mechanism of action and structural basis for these interactions.
Thomas
Biederer , Ph.D.[Associated Requests/Data] Associate Professor,
Molecular Biophysics and Biochemistry @ Yale University, New Haven, CT (USA) Subgroup(s): [Glycans in development and physiology
]
Research interests: This laboratory aims to determine how adhesive interactions organize synapses in the brain. Specifically, this group focuses on the structural and functional regulation of SynCAM (Synaptic Cell Adhesion Molecules) immunoglobulin (Ig) proteins by N-glycans.
G Eric
Blair , Ph.D. Reader,
Biochemistry and Molecular Biology @ University of Leeds (UK) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory focuses in cell surface glycoproteins and glycosyl groups that interact with viruses that infect human cells and cause disease
Jesse
Bloom , PhD[Associated Requests/Data] Principal Investigator,
Fred Hutchinson Cancer Research Center Subgroup(s): [To be Assigned]
Research interests: Characterizing mutant N1 neuraminidase proteins with receptor-binding function in influenza
Bruce S.
Bochner , M.D.[Associated Requests/Data] Professor, Medicine and Director,
Division of Allergy and Clinical Immunology @ Johns Hopkins University School of Medicine, Baltimore, MD (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory focuses on the role of cell adhesion molecules in allergic inflammation. One main area of ongoing research is examining the function, expression and ligands for Siglec-8 and Siglec-F on eosinophils and Siglec-8 on mast cells.
Geert-Jan
Boons , Ph.D. Professor,
Dept of Chemistry @ Complex Carbohydrate Research Center, University of Georgia, Athens, GA (USA) Subgroup(s): [Glycans in immune recognition and function
, Glycans in cancer biology, Glycan synthesis and microarrays
]
Research interests: The laboratory focuses in the areas of synthetic and biological chemistry with an emphasis on the development of efficient methods for glycoconjugate synthesis, preparation of glycoconjugates of biological importance, studying cellular activation by bacterial cell wall components and the development of fully synthetic vaccines.
Nicolai
Bovin , Ph.D.[Associated Requests/Data] Head of Laboratory of Carbohydrate Chemistry,
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow (Russian Federation) Subgroup(s): [Glycans in immune recognition and function
, Glycan synthesis and microarrays
]
Research interests: Dr. Bovin's group is focused on chemical synthesis of sulphated, sialylated, and galactosylated oligosaccharides and neoglycoconjugates. This laboratory also investigates the specificity of animal lectins both on the molecular and cellular level and is currently involved in the design of glycoarrays as a tool for investigating lectin specificity.
Kenneth
Bradley , Ph.D. [Associated Requests/Data] Assistant Professor,
Dept. of Microbiology, Immunology, & Molecular Genetics @ University of California, Los Angeles, CA (USA) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory focuses on host-pathogen interactions, specifically related to interactions of bacterial toxins with mammalian target cells
Curtis
Brandt , Ph.D.[Associated Requests/Data] Professor and Vice Chair Research,
Department of Ophthalmology and Visual Sciences @ University of Wisconsin Medical School, Madison, WI (USA) Subgroup(s): [Structural glycobiology]
Research interests: This laboratory is studying the role of the carbohydrate chains on viral envelope glycoproteins in various processes.
Michael B.
Brenner , M.D.[Associated Requests/Data] Professor,
Division of Rheumatology, Immunology and Allergy @ Harvard Medical School, Brigham and Women's Hospital, Boston, MA (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: Dr. Brenner's laboratory is defining the glycolipid antigens in the CD1 antigen presentation system. The CD1a, b, c, and d molecules bind glycolipid antigens in subcompartments of the endocytic system and traffic them to the cell surface for presentation to T lymphocytes. Studies on the specificity and structure of the lipid for binding to CD1 and for the glycan for recognition by the T cell antigen receptor are at the core of understanding how this system of antigen presentation works.
C. Fred
Brewer , Ph.D. Professor,
Department of Molecular Pharmacology @ Albert Einstein College of Medicine, Bronx, NY (USA) Subgroup(s): [Glycans in cancer biology, Glycans in immune recognition and function
, Structural glycobiology]
Research interests: This laboratory is studying the structure-function relationships of the galectins and other lectins including their binding specificities, quaternary structures and cross-linking activities in relation to their biological activities using isothermal titration microcalorimetry, electron microscopy, and x-ray crystallography.
Christopher
Buck , null[Associated Requests/Data] Scientist,
NIH Subgroup(s): [To be Assigned]
Research interests:
Esther
Bullitt , Ph.D[Associated Requests/Data] Assistant Professor,
Dept. of Physiology & Biophysics @ Boston University School of Medicine, Boston, MA (USA) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory studies the structures and functions of the macromolecular assemblies involved in bacterial adhesion.
Jane
Burns , M.D.[Associated Requests/Data] Professor,
Department of Pediatrics @ UCSD, La Jolla, CA (USA) Subgroup(s): [To be Assigned]
Research interests: This laboratory is focus on human disease that is characterized by immune destruction of the arterial wall and myocardium.
Michael
Caparon , Ph.D.[Associated Requests/Data] Associate Professor,
Department of Molecular Microbiology @ Washington University, St. Louis, MO (USA) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory is focusing on glycan-binding domain functions in either the translocation process or in the cytotoxicity of the NAD-glycohydrolase toxin( SPN)
Jason A.
Carlyon , Ph.D[Associated Requests/Data] Assistant Professor,
Deptt of Microbiology & Immunology @ Virginia Commonwealth University School of Medicine, Richmond, VA (USA) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory is studying Anaplasma phagocytophilum, the causative agent of human granulocytic anaplasmosis (ehrlichiosis). We are interested in identifying and characterizing the bacterial adhesins/ invasins that mediate attachment to and entry of neutrophils through interactions with PSGL-1, sLex, and alpha2,3-sialic acid and alpha 1,3-fucose residues
Jose M.
Casasnovas , Ph.D. Associate Professor,
Dept. of Macromolecule Structure @ Campus Universidad Autonoma, Madrid (Spain) Subgroup(s): [Structural glycobiology]
Research interests: This laboratory focuses on the characterization of glycans and glycan binding properties of immune receptors.
Roger
Chammas , M.D., Ph.D.[Associated Requests/Data] Associate Professor,
Division of Oncology @ University of Sao Paulo Medical School, Sao Paulo (Brazil) Subgroup(s): [Glycans in cancer biology, Glycans in immune recognition and function
]
Research interests: Dr. Chammas' laboratory is exploring a galectin-3 KO model, evaluating how inflammation and tumorigenesis develop in galectin-3 null tissue environments. This laboratory is also exploring the functions of gangliosides in cell migration and antigen presentation, with the aim of understanding how these glycoconjugates may interfere with tumor progression.
Chuan-Fa
Chang , Ph.D[Associated Requests/Data] Assistant Professor,
Medical Technology @ National Cheng Kung University, Tainan (Taiwan) Subgroup(s): [Glycomics and glycoinformatics, Glycans in cancer biology]
Research interests: This laboratory is exploring the carbohydrate-protein interaction and investigating the regulation of glycosyltransferases and the alteration of glycan structures during tumor progression or metastasis.
Songming
Chen , Ph.D.[Associated Requests/Data] Assistant Professor,
Institute for Hepatitis, Pennsylvania Commonwealth Institute, Doylestown, PA (USA) and Virus Research, Subgroup(s): [To be Assigned]
Research interests: How IgG glycosylation affect its function, and the use of IgG glycosylation as a disease biomarker.
Pi-Wan
Cheng , Ph.D.[Associated Requests/Data] Professor,
Department of Biochemistry and Molecular Biology @ University of Nebraska Medical Center, Omaha, NE (USA) Subgroup(s): [Glycans in cancer biology]
Research interests: This laboratory studies the structures, biosynthesis, and functions of mucin glycans
Gary F.
Clark , Ph.D.[Associated Requests/Data] Associate Professor,
Obstetrics, Gynecology @ University of Missouri-Columbia, Columbia, MO (USA) Subgroup(s): [Glycans in development and physiology
, Glycans in immune recognition and function
, Glycans in cancer biology]
Research interests: Dr. Clark is interested in (1) mammalian sperm-egg binding; (2) induction of tolerance to the mammalian embryo/fetus and gametes mediated by glycoproteins expressed in the reproductive system; and (3) pathogens or tumor cells that either acquire or mimic the carbohydrate sequences employed as functional groups for the induction of tolerance essential for reproduction. This subterfuge enables the pathogen or tumor cell to couple its survival to the reproductive imperative.
Mary
Cloninger , Ph.D.[Associated Requests/Data] Associate Professor,
Department of Chemistry and Biochemistry @ Montana State University, Bozeman, MT (USA) Subgroup(s): [Glycans in cancer biology]
Research interests: This group is focused on the uses of sugar-functionalized dendrimers of varying sizes and with varying loadings of sugars to study multivalent protein-carbohydrate interactions.
Brian A.
Cobb , Ph.D.[Associated Requests/Data] Assistant Professor,
Dept. of Pathology @ Case Western Reserve University, Cleveland, OH (USA) Subgroup(s): [Structural glycobiology, Glycans in immune recognition and function
]
Research interests: This laboratory is focused upon the mechanisms of carbohydrate-mediated T cell activation and the necessary interactions between class II MHC molecules, T cell receptors, and bacterial polysaccharide antigens
Jenifer
Coburn , Ph.D.[Associated Requests/Data] Professor,
edicine (Division of Infectious Disease), and Center for Infectious Disease Research @ Medical College of Wisconsin, Milwaukee, WI (USA) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory is focusing on identify mammalian cell surface receptors for Leptospira interrogans.
Scott P.
Commins , Ph.D. Assistant Professor,
Department of Medicine @ University of Virginia, Charlottesville, VA (USA) Subgroup(s): [To be Assigned]
Research interests: This laboratory is focused on IgE response to carbohydrate epitopes and the role of that IgE in food allergy and anaphylaxis
Angel L.
Corbi , Ph.D.[Associated Requests/Data] Professor,
Upper Council for Scientific Research @ Consejo Superior de Investigaciones Científicas, CSIC, Madrid (Spain) Subgroup(s): [Glycans in development and physiology
, Glycans in cancer biology, Glycans in immune recognition and function
]
Research interests: Dr. Corbi's laboratory is interested in 1) the identification of the molecular mechanisms controlling dendritic cell differentiation and dendritic cell-specific gene expression and 2) the relevance of DC-SIGN and other cell surface lectins in the differentiation and functional maturation of human dendritic cells.
Brendan
Cormack , Ph.D[Associated Requests/Data] Assistant Professor,
Molecular Biology & Genetics @ The Johns Hopkins University School of Medicine (USA) Subgroup(s): [To be Assigned]
Research interests: This laboratory analyzes the molecular basis for host-pathogen interactions in pathogenic Candida species, primarily Candida glabrata; we are focusing understanding the physiological role of C. glabrata lectins in mediating host interaction.
Daniel J.
Cosgrove , Ph.D. Professor,
Department of Biology @ Penn State University, PA (USA) Subgroup(s): [Structural glycobiology]
Research interests: This laboratory is studying the structure and function of grass pollen allergens that cause season hayfever and asthma.
Fasseli
Coulibaly , Ph.D.[Associated Requests/Data] Chief Investigator,
Faculty of Medicine, Nursing and Health Sciences @ Monash University, Clayton, Victoria (Australia) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory is focusing on the structure-function of viral proteins involved in assembly and virulence of animal viruses
Eric
Cox , Ph.D.[Associated Requests/Data] Professor,
Laboratory of Immunology @ Ghent University, Faculty of Veterinary Medicin (Belguim) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: his laboratory is focusing on identifying bacterial or plant lectins that interact with mammalian glycoproteins or glycolipids as well as study this interaction
Predrag
Cudic , null[Associated Requests/Data] Associate Member,
Torrey Pines Institute for Molecular Studies Subgroup(s): [To be Assigned]
Research interests:
Geesje M.
Dallinga-Thie , Ph.D.[Associated Requests/Data] Senior Scientist,
Experimental Vascular Medicine @ AMC Amsterdam (the Netherlands) Subgroup(s): [To be Assigned]
Research interests: This laboratory is involved in studies on the role of proteoglycans in glucose and triglyceride metabolism. We perform human, mouse and cell culture studies to gain more insight in the pathophysiology of derangements in HSPG composition
Fabio
DallOlio , Ph.D.[Associated Requests/Data] Associate Professor,
Dept. Experimental Pathology @ University of Bologna (Italy) Subgroup(s): [Glycans in cancer biology]
Research interests: This laboratory focuses on the mechanisms linking cancer-related glycosylation changes with the phenotype of cancer cells
Anthony
dApice , M.D., Ph.D.[Associated Requests/Data] Professor & Director,
Immunology Research Centre and Department of Medicine @ University of Melbourne, St Vincent’s Hospital, Victoria (Auatralia) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory focuses on transplant immunology - particularly xenotransplantation and the generation of genetically modified pigs for ultimate use as organ / tissue donors to humans.
Brian
Dean , Ph.D. Head of Laboratory,
of the Rebecca L. Cooper Research Laboratories @ Mental Health Research Institute, Victoria (Australia) Subgroup(s): [Glycomics and glycoinformatics, Glycans in development and physiology
, Structural glycobiology, Glycan synthesis and microarrays
]
Research interests: This laboratory studies the molecular cytoarchitecture of human postmortem CNS as a strategy to understand the underlying pathologies of psychiatric disorders and uses a number of model systems to study the mechanism of action of antipsychotic and mood stabilising drugs. Central to this approach is the use of 2D electrophoresis to screen for proteins that are affected by the pathologies of disease or drug treatment.
Champion CS
Deivanayagam , Ph.D.[Associated Requests/Data] Assistant Professor,
Department of Vision Sciences @ University of Alabama, Birmingham, AL (USA) Subgroup(s): [To be Assigned]
Research interests: This laboratory is investigating the structural and functional aspects of the surface protein Antigen I/II of Streptococcus mutans
Anne
Dell , Ph.D., F.R.S.[Associated Requests/Data] BBSRC Research Professor,
Department of Biological Sciences @ Imperial College of Science, Technology and Medicine, London (United Kingdom) Subgroup(s): [Glycomics and glycoinformatics]
Research interests: Dr. Dell's research is focused on the development and application of high sensitivity mass spectrometric strategies for solving biopolymer structural problems, with particular emphasis on post-translational modifications, especially glycosylation. Current research projects include glycomic and glyco-proteomic studies of normal and knockout mice, parasitic nematodes, bacterial pathogens, mucins associated with cancer and cystic fibrosis, and glycoproteins implicated in mouse and human fertilization and reproduction.
James W.
Dennis , Ph.D.[Associated Requests/Data] Professor,
Department of Molecular and Medical Genetics @ Samuel Lunenfeld Research Institute & University of Toronto, Ontario (Canada) Subgroup(s): [Glycomics and glycoinformatics, Glycans in cancer biology, Glycans in immune recognition and function
]
Research interests: The research of this laboratory focuses on the role of N- and O-linked glycan chains on cell surface receptors including T-cell receptor, integrins and cytokine receptors. This laboratory examines the effects of glycan structures on receptor clustering, endocytosis, and their interaction with galectins in systems that affect cell proliferation, motility and differentiation.
Terence
Dermody , Ph.D.[Associated Requests/Data] Professor,
Pediatric and Microbiology & Immunology @ Vanderbilt University School of Medicine, Nashville, TN (USA) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory focuses on the molecular basis of reovirus binding to cell-surface carbohydrates and the role of carbohydrate binding in reovirus disease.
Charles
Dimitroff , Ph.D.[Associated Requests/Data] Assistant Professor,
Department of Dermatology @ Harvard Medical School, Brigham and Women's Hospital, Boston, MA (USA) Subgroup(s): [Glycans in immune recognition and function
, Glycans in cancer biology, Glycans in development and physiology
]
Research interests: This laboratory currently studies the glyco-pathological basis of inflammation and tumor metastasis. Current research efforts include investigations on how circulating leukocytes traffic to inflamed tissues, how circulating solid tumor cells interact with endothelial linings to enhance metastatic potential, and how treatment with analogs of glucosamine disrupt leukocyte trafficking mechanisms and/or influence effector/regulatory function of T cells.
Ken
Dimock , Ph.D. Professor,
Dept of Biochemistry, Microbiology & Immunology @ University of Ottawa, Ontario (Canada) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory studies virus binding and entry, with a current focus on the role of sialic acid in these processes.
Kan
Ding , Ph.D. Professor,
Glycochemistry & Glycobiology @ Shanghai Institute of Materia Medica (China) Subgroup(s): [Glycans in cancer biology]
Research interests: This laboratory focuses on understanding of the structure and function of proteoglycans in diseases. In addition, studying on carbohydrate-based drug discovery
Ruud P.M.
Dings , Ph.D. Assistant Professor,
Department of Biochemistry @ University of Minnesota, Minneapolis, MN (USA) Subgroup(s): [To be Assigned]
Research interests: This laboratory is studying and developing Galectin targeting therapeutics as anti-cancer treatments.
Steven
Domino , M.D., Ph.D.[Associated Requests/Data] Assistant Professor,
Department of Obstetrics and Gynecology @ University of Michigan, Ann Arbor, MI (USA) Subgroup(s): [Glycans in cancer biology, Glycans in host-microbe interactions]
Research interests: Dr. Domino's laboratory is studying the tissue-specific expression and regulation of Fut1 and Fut2, and identifying the carbohydrate structures and cell types involved in Fut1 and Fut2 function in reproductive tissues and cancer.
Kurt
Drickamer , Ph.D.[Associated Requests/Data] Professor,
Division of Molecular Biosciences @ Imperial College (United Kingdom) Subgroup(s): [Glycans in immune recognition and function
, Glycans in development and physiology
]
Research interests: Dr. Drickamer's laboratory is interested in the structure, function and evolution of C-type lectins involved in innate immunity, cell-cell adhesion and turnover of serum glycoproteins. This laboratory's primary emphasis is on developing a molecular understanding of how these proteins perform their biological functions.
Thomas
Edgington , M.D.[Associated Requests/Data] Professor,
Department of Immunology @ The Scripps Research Institute, La Jolla, CA (USA) Subgroup(s): [Structural glycobiology]
Research interests: This laboratory studies the interactions on vascular endothelial cells that involve sulfated oligosaccharide chains with particular focus on the Chondroitins.
Jeffrey
Esko , Ph.D.[Associated Requests/Data] Professor,
Department of Cellular & Molecular Medicine @ UCSD, La Jolla, CA (USA) Subgroup(s): [Glycans in cancer biology, Glycans in development and physiology
]
Research interests: Dr. Esko's laboratory focuses on the structure, function, and biosynthesis of glycoproteins and proteoglycans. This laboratory also works on the design and synthesis of small molecule inhibitors of glycosylation.
Neil
Fairweather , Ph.D.[Associated Requests/Data] Professor,
Centre for Molecular Microbiology and Infection @ Imperial College London (United Kingdom) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory focuses on mechanisms used by bacterial pathogens to cause disease. Of particular interest is the structure and function of bacterial virulence factors from the pathogenic Clostridia.
Ronald
Falk , M.D.[Associated Requests/Data] Professor,
Division of Nephrology & Hypertension @ The University of North Carolina, Chapel Hill, NC (USA) Subgroup(s): [To be Assigned]
Research interests: This laboratory is studying the pathogenesis of two human autoimmune kidney diseases, anti-glycan antibodies and ANCA vasculitiss
Fang
Fang , M.D., Ph.D.[Associated Requests/Data] Chief Scientific Officer (CSO),
Co-founded @ NexBio, Inc., San Diego, CA (USA) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory focuses in the elucidating the glycan-specificity of a sialidase-fusion protein (DAS181) and the mechanism of viral-resistance to the cleavage of these sialylated-glycans by DAS181
Mark
Farrell , null[Associated Requests/Data] professor,
University of Kanses Subgroup(s): [To be Assigned]
Research interests:
Ann
Feeney , Ph.D.[Associated Requests/Data] Associate Professor,
Dept of Immunology @ The Scripps Research Institute, La Jolla, CA (USA) Subgroup(s): [To be Assigned]
Research interests: This laboratory is involved in studies of the differences in the composition of the antibody repertoire in different B cell subsets.
Mario
Feldman , null[Associated Requests/Data] Associate Professor,
Washington University School of Medicine St Louis Subgroup(s): [To be Assigned]
Research interests:
Elena
Fernandez-Ruiz , Ph.D. Senior Scientist,
Department of Molecular Biology @ Hospital Universitario de la Princesa, Madrid (Spain) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory focuses on the functional characterization of human C-type lectins DLEC/BDCA-2, DECTIN-1 and KLRF1 and molecular characterization of new C-type lectin genes.
Ana
Fernandez-Sesma , Ph.D. [Associated Requests/Data] Assistant Professor,
Microbiology @ Mount Sinai Medical Center, New York, NY (USA) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: his laboratory is focusing in the evasion of immunity by viruses in primary human cells and receptor binding by those viruses constitutes an important element in their induction or evasion of immune responses.
Susan
Fisher , Ph.D.[Associated Requests/Data] Professor,
Dept of Cell & Tissue Biology @ University of California, San Francisco, CA (USA) Subgroup(s): [Glycans in cancer biology]
Research interests: This laboratory studies the structural basis of carbohydrate function in terms of adhesion and other biological processes.
Howard S.
Fox , M.D., Ph.D.[Associated Requests/Data] Professor,
Department of Pharmacology and Experimental Neuroscience @ University of Nebraska Medical Center, Omaha, NE (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory studying the infection of rhesus monkeys infected with SIV as a model for HIV/AIDS, focusing on central nervous system infection, immunity, and brain dysfunction that develops following infection.
Daron I.
Freedberg , Ph.D.[Associated Requests/Data] Senior Staff Fellow,
Center for Biologics Evaluation and Research, Food and Drug Administration @ NIH, Rockville, MD (USA) Subgroup(s): [Structural glycobiology]
Research interests: Dr. Freedberg's laboratory is interested in discovering carbohydrate structure-function relationships through the study and systematic design of novel protein-binding carbohydrate scaffolds, structures of carbohydrate-based cancer and polysaccharide vaccines, Lewis antigens and blood group oligosaccharides. This laboratory plans to generate carbohydrate libraries through chemo-enzymatic synthesis, and study the structures of these novel compounds to delineate structure-function relationships, which will be used to develop potent carbohydrate-based inhibitors of galectin-3.
Alan B.
Frey , Ph.D. Associate Professor,
Department of Cell Biology @ New York University School of Medicine, New York, NY (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: Dr. Frey's laboratory focuses on the understanding of the role that inhibitory signaling receptors expressed in murine CD8+ T cells play in causing the lytic-defective phenotype which characterizes tumor infiltrating lymphocytes.
Susan C.
Frost , Ph.D. Professor,
Department of Biochemistry and Molecular Biology @ University of Florida, Gainesville, FL (USA) Subgroup(s): [Glycans in immune recognition and function
, Glycans in cancer biology]
Research interests: This laboratory is focusing on the role of carbonic anhydrase IX (CAIX) in the development of the glycolytic phenotype in breast cancer cells
Robert
Fuhlbrigge , M.D., Ph.D. Assistant Professor,
Harvard Skin Disease Research Center, Harvard University, Boston, MA(USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory studies the structure and regulation of T cell selectin ligands and their role in the development of inflammatory skin disease.
Michiko N.
Fukuda , Ph.D.[Associated Requests/Data] Professor,
Cancer Research Center @ The Burnham Institute, La Jolla, CA (USA) Subgroup(s): [Glycans in cancer biology]
Research interests: This laboratory studies carbohydrate-dependent cancer metastasis. We also study on the biosynthesis of N-glycans focusing on the Golgi processing alpha-mannosidase IIx.
Jorge
Galan , PhD, DVM[Associated Requests/Data] Professor and Chairman,
Yale University Subgroup(s): [To be Assigned]
Research interests:
Gonzalo
Garcia , Ph.D. Investigator,
Department of Pathology @ University of Michigan, Ann Arbor, MI (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory is focus on the mechanism of how polysaccharides can regulation TCR signaling in the different population of T cells, and how the differentiation and activation of T cells affects may surface glycosylation and function.
Brian
Geisbrecht , Ph.D.[Associated Requests/Data] Assistant Professor,
Division of Cell Biology and Biophysics @ University of Missouri-Kansas City, MO (USA) Subgroup(s): [To be Assigned]
Research interests:
Yu
Geng , M.D.[Associated Requests/Data] President,
ProSci, Inc., Poway, CA (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory is studying the interactions of carbohydrates on viral envelope glycoproteins with C-type lectins on immune cells and developing prophylactic vaccines against HIV and other virus.
Matthew
Gentry , Ph.D.[Associated Requests/Data] Assistant Professor,
Dept of Molecular and Cellular Biochemistry @ University of Kentucky, Lexington, KY (USA) Subgroup(s): [Structural glycobiology]
Research interests: This laboratory focuses on a carbohydrate binding protein that when mutated results in a fatal neurodegenerative disease called Lafora disease.
Thomas A.
Gerken , Ph.D.[Associated Requests/Data] Professor,
Depts of Pediatrics and Biochemistry @ Case Western Reserve University, School of Medicine, BRB, Cleveland, OH (USA) Subgroup(s): [Glycomics and glycoinformatics, Structural glycobiology, Glycans in cancer biology]
Research interests: This laboratory is focused on understanding the roles of polypeptide sequence on the elongation/biosynthesis of mucin type O-glycans. Our studies have lead to the development of numerical approaches for characterizing transferase specificity and the modeling / predicting of site-specific mucin O-glycosylation.
James E.
Gern , M.D.[Associated Requests/Data] Professor,
Department of Pediatrics @ University of Wisconsin, Madison, WI (USA) Subgroup(s): [Glycans in immune recognition and function
, Glycans in host-microbe interactions]
Research interests: This laboratory is focusing on identifying and comparing the carbohydrate binding properties of purified preparations of two different rhinoviruses: HRV-C15 and HRV-A16. This information will be used to help identify the rhinovirus-C species viral receptor.
Friederike
Gieseke , Ph.D. Scientist,
Forschungsinstitut Kinderkrebs-Zentrum Hamburg (Germany) Subgroup(s): [To be Assigned]
Research interests: This laboratory is studying (i) the role of galectins in immunomodulatory functions of mesenchymal stromal cells (ii) functions of members of the siglec family and (iii) the role of glycosylation in tumor immune escape mechanisms.
Ilene
Gipson , Ph.D.[Associated Requests/Data] Sr. Scientist and Professor,
Dept of Ophthalmology @ Harvard Medical School, Boston, MA (USA) Subgroup(s): [Glycans in host-microbe interactions, Glycans in development and physiology
, Glycan synthesis and microarrays
]
Research interests: Dr. Gipson's laboratory focuses on the characterization of the carbohydrate portion of ocular surface epithelial mucins. This laboratory also plans to investigate how the differential expression of glycosyltransferases (i.e. sialyltransferases) and/or glycosydases regulates the production of terminal carbohydrate ligands on mucins.
Jorge
Giron , Ph.D.[Associated Requests/Data] Associate Professor,
Department of Molecular Genetics and Microbiology @ University of Florida, Gainesville, FL (USA) Subgroup(s): [To be Assigned]
Research interests: This laboratory is focus on the identification and role of pili structures that mediate bacterial attachment to host cells.
David
Goldberg , Ph.D.[Associated Requests/Data] Research Fellow,
Palo Alto Research Center, Palo Alto, CA (USA) Subgroup(s): [Glycomics and glycoinformatics]
Research interests: Dr. Goldberg's research interest is in applying mathematics and algorithms to biological problems. He has recently been focusing on automatic interpretation of mass spectra from proteins and glycans.
Irwin J.
Goldstein , Ph.D.[Associated Requests/Data] Professsor,
Department of Biological Chemistry @ University of Michigan, Ann Arbor, MI (USA) Subgroup(s): [Glycans in immune recognition and function
, Glycans in cancer biology]
Research interests: Dr. Goldstein's laboratory studies carbohydrate-protein interactions using lectins. We are especially interested in lectins with novel carbohydrate binding properties that can be used for biomedical applications. These include the lectins from Polyporus squamosus fungus which recognizes Neu5Ac alpha2,6-Gal beta1,4GlcNAc sequences present in Asn-linked glycoproteins, and the mushroom Marasmius oreades which binds the Gal alpha1,3Gal beta1,4GlcNAc xenotransplantation antigen with high affinity.
David F.
Green , Ph.D. [Associated Requests/Data] Assistant Professor,
Dept. of Applied Math & Statistics @ Stony Brook University, New York (USA) Subgroup(s): [Structural glycobiology, Glycans in host-microbe interactions]
Research interests:
This laboratory is focused on the use of computational modeling and
design approaches to the rational engineering of improved affinity and
specificity into naturally-occurring virucidal lectins, and to the
understanding of fundamental properties of protein-carbohydrate
interactions
Jenny
Gumperz , Ph.D. Assistant Professor,
Department of Immunology @ University of Wisconsin, Madison, WI (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory focuses on understanding how TCRs recognize their antigens, the specific mechanisms by which they become activated, and their physiological functions.
Brian
Haab , Ph.D.[Associated Requests/Data] Scientific Investigator,
Laboratory of Cancer Immunodiagnostics @ Van Andel Research Institute, Grand Rapids, MI (USA) Subgroup(s): [Glycans in cancer biology]
Research interests: This laboratory is studying cancer-associated changes in glycan expression and immunoreactivity and developing diagnostic tools based on those measurements.
Senitiroh
Hakomori , M.D., Ph.D.[Associated Requests/Data] Professor,
Pathobiology and Microbiology @ University of Washington Head,
Division of Biomembrane Research @ Pacific Northwest Research Institute, Seattle, WA (USA) Subgroup(s): [Glycans in development and physiology
, Glycans in cancer biology]
Research interests: Dr. Hakomori's studies are focused on microdomain structure and function that mediate receptor-induced signal transduction. For example, carbohydrate-dependent adhesion induces activation of Src family kinases, leading to MAP kinase activation and phenotypic change of various types of cells.
Robert S.
Haltiwanger , Ph.D. Professor,
Department of Biochemistry and Cell Biology @ State University of New York at Stony Brook, Stony Brook, NY (USA) Subgroup(s): [Structural glycobiology, Glycans in development and physiology
, Glycomics and glycoinformatics]
Research interests: Dr. Haltiwanger's laboratory studies the role of glycosylation in regulation of signaling events. In particular, this laboratory analyzes how O-fucose and O-glucose modifications modulate the function of proteins such as Notch.
Marie
Hanigan , Ph.D.[Associated Requests/Data] Professor,
Cell Biology @ University of Oklahoma Health Sciences Center, Oklahoma City, OK (USA) Subgroup(s): [Glycans in cancer biology]
Research interests: This laboratory is investigating glycan-based cancer biomarkers. Our initial studies have focused on the glycosylation of the enzyme gamma-glutamyl transpeptidase.
Donald
Harn , Ph.D.[Associated Requests/Data] Professor,
Dept. of Infectious Diseases @ University of Georgia, Athens, GA (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory focusses on immunomodulatory carbohydrates, specifically in their ability to induce Th2-type T cell responses, activate macrophages and dendritic cells and to also drive immune suppression.
Adrian L.
Harris , Ph.D.[Associated Requests/Data] Professor,
Department of Medical Oncology @ University of Oxford (United Kingdom) Subgroup(s): [Glycans in cancer biology]
Research interests: This laboratory is focused in tumour angiogenesis and the mechanisms of resistance to antiangiogenic therapy.
Peter B.
Hedlund , M.D., Ph.D.[Associated Requests/Data] Assistant Professor,
Dept of Molecular Biology @ The Scripps Research Institute, La Jolla, CA (USA) Subgroup(s): [Glycomics and glycoinformatics, Glycan synthesis and microarrays
]
Research interests: This laboratory focuses to identify new targets for the treatment of
depression. Currently our work is focused on the serotonin 5-HT7 receptor.
This receptor shows many characteristics that makes it interesting in
depression. Blockade or inactivation of the 5-HT7 receptor leads to changes
consistent with being in a more 'anti-depressed' state..
Jerry
Hedrick , Ph.D. Professor Of Biochemistry,
Department of Animal Science @ University of California Davis, Davis, CA (USA) Subgroup(s): [Glycans in development and physiology
, Structural glycobiology]
Research interests: This laboratory is studying a lectin-ligand mechanism responsible for establishing a block to polyspermy at fertilization. They are also determining the structure of an egg glycoprotein ligand responsible for sperm-egg binding.
Viola
Heinzelmann-Schwarz , MD Group Leader,
University of New South Wales Subgroup(s): [To be Assigned]
Research interests: Biomarkers for early detection and personalized therapy and to understand the underlying mechanisms of development of epithelial ovarian cancer with current focus to understand the biological role of certain glycans such as P1 and Pk in gynaecological cancer (ovarian, tubal, peritoneal) development and progression.
Timothy
Henion , Ph.D.[Associated Requests/Data] Research Assistant Professor,
Cell Biology @ University of Massachusetts Medical School, Waltham, MA (USA) Subgroup(s): [Glycans in development and physiology
]
Research interests: Our laboratory focuses on glycan function during nervous system development. We primarily use the olfactory system as our model to investigate 1) the influence of Fringe glycosylation and Notch signaling on olfactory cell fate; 2) the role of protein-glycan interactions in patterning of sensory neuron projections to the CNS.
Bernard
Henrissat , Ph.D. Head of Glycobiology: Genomes and Structures,
Architecture et Fonction des Macromolecules Biologiques, Marseille (France) Subgroup(s): [Glycomics and glycoinformatics]
Research interests: Dr. Henrissat's group is currently active in bioinformatics related to Glycobiology (maintenance of the CAZy database http://afmb.cnrs-mrs.fr/CAZY/classification of carbohydrate-active enzymes in families) and in crystal structure determinations of carbohydrate-active enzymes (glycoside hydrolases and glycosyltransferases) and modules thereof.
Michael
Hensel , Ph.D. [Associated Requests/Data] Professor,
Div. Microbiology, Dept. Biology/Chemistry @ University of Osnabrueck (Germany) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory investigating bacterial adhesins. The focus is on the gastrointestinal pathogen Salmonella enterica that possesses a large number of adhesive structures
Ole
Hindsgaul , Ph.D.[Associated Requests/Data] Professor,
Carbohydrate Chemistry @ Carlsberg Laboratory, Copenhagen (Denmark) Subgroup(s): [Glycan synthesis and microarrays
, Glycomics and glycoinformatics]
Research interests: This laboratory focuses on the development of new tools for the detection,
separation and structural characterization of complex carbohydrates.
Special emphasis is on tools that can be used without sophisticated
instrumentation.
R. Jean
Hine , Ph.D. Professor,
Dietetics and Nutrition, Winthrop P. Rockefeller Cancer Institute @ University of Arkansas, Little Rock, AR (USA) Subgroup(s): [Glycans in cancer biology]
Research interests: This laboratory is examining nutritional biomarkers that characterize the end result of the interaction of diet, other environmental variables and endogenous host factors (gene expression and post translational modifications).
Mitchell
Ho , Ph.D.[Associated Requests/Data] Head,
Antibody Therapy Unit, Laboratory of Molecular Biology @ NCI, Bethesda, MD (USA) Subgroup(s): [Glycans in cancer biology]
Research interests: This laboratory studies the basic and translational science related to the
development of novel antibody therapy in malignant tumors.
Shawn
Hochman , Ph.D.[Associated Requests/Data] Associate Professor,
Department of Physiology @ Emory University School of Medicine, Atlanta, GA (USA) Subgroup(s): [To be Assigned]
Research interests: This laboratory is studying mechanisms of tetanus toxin C -fragment (TTC) transport in vivo.
Rikard
Holmdahl , M.D., Ph.D.[Associated Requests/Data] Professor,
Dept of Medical Biochemistry and Biophysics @ Karolinska Institute, Stockholm (Sweden) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory studying sotstanslational modifcation of autoantigens. Recognition of carbohydrastes in antigen presentation.
Zonglie
Hong , Ph.D. Assistant Professor,
University of Idaho, Moscow, ID (USA) Subgroup(s): [Glycans in development and physiology
]
Research interests: This laboratory studying a group of lectin domain-containing receptor-like kinases (lecRKs) in plants.
Lora V.
Hooper , Ph.D.[Associated Requests/Data] Assistant Professor,
Center for Immunology @ University of Texas Southwestern Medical Center at Dallas, TX (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory is studying a group of C-type lectins (the Reg family) that are abundantly expressed in the small intestines of mice and humans, and whose expression is regulated by interactions with commensal bacteria.
Amy R.
Howell , Ph.D. Associate Professor, Associate Department Head,
Department of Chemistry @ University of Connecticut, Storrs, CT (USA) Subgroup(s): [Glycan synthesis and microarrays
, Glycans in immune recognition and function
]
Research interests: Dr. Howell's research is focused on the development of synthetic methodology that provides straightforward access to sphingosines, sphinganines and phytosphingosines. These key precursors are converted to glycosylceramides for probing the relationship between structure and function in glycolipid antigen presentation by the CD1 family.
Shie-Liang
Hsieh , Ph.D.[Associated Requests/Data] Professor,
Department of Microbiology and Immunology @ National Yang-Ming University, Taipei (Taiwan) Subgroup(s): [Glycans in immune recognition and function
, Glycans in cancer biology]
Research interests: This laboratory studies the mechanisms of decoy receptor 3 (DcR3), a member of tumor necrosis factor receptor superamily, to modulate the function of dendritic cells and macropahges. In additon, exploring the lectin receptors and Ig superfamily specifically expressed on liver macrophage--Kuppfer cell.
Shau-Ku
Huang , Ph.D. [Associated Requests/Data] Associate Professor,
Department of Medicine @ Johns Hopkins University, Baltimore, MD (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory focuses in the role of lectin receptors through their interactions with a repertoire of glycoantigens on the expression of allergic diseases
Shashikala
Inamdar , Ph.D.[Associated Requests/Data] Professor,
Department of Biochemistry @ Karnatak University, Dharwad (India) Subgroup(s): [Glycans in cancer biology]
Research interests: This laboratory focused in lectins from fungi & plants, studying their interaction with cell surface molecules for their possible application in cancer research.
Julie M.
Jameson , Ph.D.[Associated Requests/Data] Assistant Professor,
Department of Immunology and Microbial Science @ The Scripps Research Institute, La Jolla, CA (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory is focused on how the obese environment impacts T cell and epithelial cell glycosylation and how this contributes to impaired epithelial cell homeostasis and barrier function
Stephen C.
Jameson , Ph.D.[Associated Requests/Data] Associate Professor,
Department of Laboratory Medicine and Pathology @ University of Minnesota, Minneapolis (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: Dr. Jameson's research focus is on development and regulation of lymphocytes, especially T cells. Recent work has suggested that differential glycosylation effects the sensitivity of the T cell receptors and its coreceptors, suggesting that regulation of glycosylation may be a critical element in controlling T cell development, survival and functional activity.
Caroline
Jefferies , PhD[Associated Requests/Data] Senior Lecturer,
Royal College of Surgeons Subgroup(s): [To be Assigned]
Research interests:
Knud J.
Jensen , Ph.D[Associated Requests/Data] Professor,
Department of Basic Sciences and Environment/Bioorganic Chemistry @ University of Copenhagen (Sweden) Subgroup(s): [To be Assigned]
Research interests: This laboratory is studying in synthetic bioorganic chemistry and nanobioscience, with a focus on carbohydrates.
Xi Jason
Jiang , Ph.D.[Associated Requests/Data] Professor,
Department of Pediatrics @ Cincinnati Children's Hospital Medical Center, Cincinnati, OH (USA) Subgroup(s): [To be Assigned]
Research interests:
Lokesh
Joshi , Ph.D. Professor,
Glycoscience @ National University of Ireland, Galway (Ireland) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory is studying host-pathogen interactions, specifically the role of sugar-lectins in this relationship.
Yoshihide
Kanaoka , M.D., Ph.D.[Associated Requests/Data] Assistant Professor,
Department of Medicine @ Harvard Medical School, Brigham and Women's Hospital, Boston, MA (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory is focusing on the mechanism by which glycans in a major
indoor allergen, house dust mite, initiate an immune response via C-type
lectin receptors on dendritic cells.
Minoru
Kanehisa , Ph.D.[Associated Requests/Data] Director and Professor,
Bioinformatics Center @ Kyoto University, Kyoto (Japan) Subgroup(s): [Glycomics and glycoinformatics]
Research interests: This laboratory is focused on bioinformatics technologies and database
development for functional glycomics, especially by integrating genomic
and chemical information.
Geoffrey S.
Kansas , Ph.D.[Associated Requests/Data] Assiociate Professor,
Department of Micro-Immunology @ Northwestern University Medical School, Chicago (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory studies 1) enzymes which are involved in selectin ligand formation in leukocytes, 2) how expression of those enzymes is controlled, and 3) basic cell biology of FucT-VII.
Cheng
Kao , Ph.D.[Associated Requests/Data] Professor,
Dept of Biology @ Indiana University (USA) Subgroup(s): [To be Assigned]
Research interests: This laboratory is investigating how post-translational modifications contribute to protein function and to elucidate additional regulatory circuits for proper gene expression
Peter
Karlheinz , M.D., Ph.D.[Associated Requests/Data] Professor and Head,
Atherothrombosis and Vascular division @ Baker Heart Research Institute, Melbourne (Australia) Subgroup(s): [Structural glycobiology]
Research interests: This laboratory is exploring therapeutic glycan-mimetics to prevent and treat diseases caused by bacterial toxin.
Surender
Khurana , Ph.D.[Associated Requests/Data] Staff Scientist,
US Food and Drug Administration Subgroup(s): [To be Assigned]
Research interests: Studies the functional activity of the recombinant purified virus HA proteins from different cell substrates in binding to the different sialic acid glycoproteins.
Chwan-Chuen
King , Ph.D.[Associated Requests/Data] Professor,
Epidemiology of Infectious Disease @ National Taiwan University, Taipei (Taiwan) Subgroup(s): [To be Assigned]
Research interests: This laboratory is focusing in monitor the Taiwan's avian influenza viruses with potential entry capability to human population or NOT for public health concerns
Samantha
King , Ph.D. Assistant Professor,
The Ohio State University and Columbus Children's Hospital (USA) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory studies the ability of Streptococcus pneumoniae to sequentially deglycosylate human glycoconjugates, and the effects this deglycosylation has on colonization and disease
Karl E.
Klose , Ph.D.[Associated Requests/Data] Professor,
Dept of Biology @ University of Texas San Antonio, Texas (USA) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory is focusing in the interaction of microorganisms with eukaryotic hosts, which includes binding of various microbes to eukaryotic surfaces, and typically protein-glycan interactions.
Yuriy A.
Knirel , Ph.D., Sc.D.[Associated Requests/Data] Professor,
ND Zelinsky Institute of Organic Chemistry, Moscow (Russia) Subgroup(s): [Glycan synthesis and microarrays
]
Research interests: This laboratory is focused in the structural and immunochemical studies of specific carbohydrate antigens of bacteria aiming at classification and understanding of evolution pathways of bacteria as well as understanding mechanisms of adaptation of bacteria by phase variation of cell surface structures.
Kyoko
Kojima-Aikawa , Ph.D.[Associated Requests/Data] Scientist,
Ochanomizu University, Tokyo (Japan) Subgroup(s): [To be Assigned]
Research interests: This laboratory studying on physiological functions of several carbohydrate-binding proteins possibly involved in blood coagulation systems or tumor cell progression
Thomas R
Kozel , PhD Professor,
University of Nevada, Reno Subgroup(s): [To be Assigned]
Research interests: Microbial pathogenesis – opportunistic infections by fungi and microbial capsules
Biodefense – with an emphasis on Bacillus anthracis and Burkholderia sp.
Helmut
Kramer , Ph.D.[Associated Requests/Data] Associate Professor,
Neuroscience @ University of Texas Southwestern Medical Center, Dallas, TX (USA) Subgroup(s): [To be Assigned]
Research interests: TThis laboratory is focusing on the specific glycans that the Drosophila CG12207 protein binds via its LysM domain and is exploring the role of this binding in the physiological function of CG12207 in the regulation of membrane trafficking
Eric J.
Kremer , Ph.D. Staff Scientist,
Institut de Génétique Moléculaire de Montpellier CNRS, Montpellier (France) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory is focusing in identifying pathogen receptors and their posttrtanslational modification in specific cell types
Mitch
Kronenberg , Ph.D.[Associated Requests/Data] Scientific Director and President,
Division of Developmental Immunology @ La Jolla Institute for Allergy and Immunology La Jolla, CA (USA) Adjunct Professor, Department of Biology,
UCSD, La Jolla, CA (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: Dr. Kronenberg's main interest is in the recognition of glycolipid antigens by T lymphocytes. This includes understanding the biochemistry of their interaction with CD1 antigen-presenting molecules and T-cell antigen receptors. This laboratory is also interested in receptors involved in the uptake of glycolipid antigens, the intracellular trafficking of these antigens, and the metabolic or antigen processing events that lead to the generation of epitopes recognized by T cells.
Vipin
Kumar , Ph.D. Member, Laboratory of Autoimmunity,
Torrey Pines Institute for Molecular Studies, San Diego, CA (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: Dr. Kumar's laboratory focuses on the characterization of myelin-derived, glycolipid-reactive CD1d-restricted T cells and their physiological role in different autoimmune conditions.
Stephan
Ladisch , M.D.[Associated Requests/Data] Scientific Director,
Children's Research Institute Professor,
Pediatrics, Biochemistry and Molecular Biology @ George Washington University School of Medicine, Washington DC (USA) Subgroup(s): [Glycans in cancer biology, Glycans in immune recognition and function
]
Research interests: Dr. Ladisch's work focuses on the establishment of the biological significance of gangliosides that are shed by tumor cells, particularly those involved in pediatric cancers, including brain tumors and neuroblastoma. These studies are directed toward illuminating the hypothesis that shed gangliosides enhance tumor formation, possibly both by inhibiting the antitumor immune response and by enhancing growth factor-induced signaling and proliferation of fibrobalsts and vascular endotheilial cells in the tumor microenvironment. Delineation of the signaling pathways affected by ganglioside exposure is currently under study.
Samuel
Lai , PhD Assistant Professor,
University of North Carolina Chapel Hill Subgroup(s): [Glycans in immune recognition and function
, Glycans in host-microbe interactions, Structural glycobiology]
Research interests: My lab is focused on characterizing the biophysical barrier properties of the mucosal defense against pathogens, in particular how the immune system may work together with secreted mucins to block infections. From my current work, it is very evident that glycans play an extremely important role in mediating the low affinity interactions between pathogens-mucus, antibody-mucus and antibody-pathogens.
Chung-Yu
Lan , Ph.D.[Associated Requests/Data] Associate Professor,
National Tsing Hua University (Taiwan) Subgroup(s): [To be Assigned]
Research interests: This laboratory is focus on understanding how human antimicrobial peptides (AMPs) can inhibit microbial adherence and how AMPs can kill microbial pathogens
Cynthia K.
Larive , Ph.D. Professor,
University of California - Riverside Subgroup(s): [To be Assigned]
Research interests: Impact of glucuronic acid substitution on the chemistry of heparin-derived oligosaccharides
Christopher
Lawrence , null[Associated Requests/Data] Assistant Professor,
Virginia Tech Subgroup(s): [To be Assigned]
Research interests:
Matthew
Layne , Ph.D.[Associated Requests/Data] Assistant Professor,
Department of Biochemistry @ Boston University, MA (USA) Subgroup(s): [Glycans in development and physiology
]
Research interests: This laboratory is focusing on the discoidin domain of aortic carboxypeptidase-like protein (ACLP) mediates its effects through sugar residue binding (such as galactose)
Carlito B.
Lebrilla , Ph.D.[Associated Requests/Data] Professor,
Chemistry @ University of California Davis, CA (USA) Subgroup(s): [Glycomics and glycoinformatics, Glycans in cancer biology, Structural glycobiology]
Research interests: This laboratory is focused on the development of new mass spectrometric and separation methods for the analysis of oligosaccharides. These methods are applied to the discovery of glycan biomarkers in serum for cancer and other diseases and for understanding the roles of glycosylation in nutrition.
Benhur
Lee , M.D. Assistant Professor,
Dept. of Microbiology, Immunology, & Molecular Genetics @ UCLA, Los Angeles, CA (USA) Subgroup(s): [Glycans in immune recognition and function
, Structural glycobiology, Glycans in host-microbe interactions]
Research interests: Dr. Lee's laboratory studies 1) the structural determinants of DC-SIGN interactions with cognate viral envelopes versus its natural ligands (ICAM-2/ICAM-3) and 2) the biophysical characterization of conformational changes that occur during these receptor-ligand interactions.
Robert
Lehrer , M.D. Professor,
Department of Medicine @ UCLA, Los Angeles, CA (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: Dr. Lehrer's lab works on various endogenous antimicrobial peptides, including some that have prominent lectin-like properties and strong antiviral activity. This laboratory is interested in defining the oligosaccharides that these peptides recognize on gp120 and herpes simplex glycoproteins and would welcome hearing from anyone with similar interests.
Klaus
Ley , M.D.[Associated Requests/Data] Division Head, Professor,
Dept of Inflammation Biology @ La Jolla Institute for Allergy & Immunology, La Jolla, CA (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: Dr. Ley's group studies the role of glycosylation in selectin ligand function in vivo.
Feng
Li , PhD, DVM[Associated Requests/Data] Associate Professor,
South Dakota State University Subgroup(s): [To be Assigned]
Research interests:
DeFeng
Li , Ph.D. [Associated Requests/Data] Assistant professor,
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing (China) Subgroup(s): [Glycans in cancer biology, Structural glycobiology]
Research interests: This laboratory is focuses in determining the crystal structures of different lectins and the complexes with different carbohydrates and then revealing their structure-function relationship by mutagenesis as well as the antitumor mechanism of fungal galectins
Dan
Littman , M.D., Ph.D. Helen L. and Martin S. Kimmel Professor,
Molecular Immunology, @ New York University School of Medicine, New York, NY (USA) Subgroup(s): [Glycans in immune recognition and function
, Glycans in host-microbe interactions]
Research interests: This laboratory studies mechanisms of signal transduction, differentiation, and migration of T cells, and mechanisms of HIV entry, with an emphasis on the role of dendritic cells in viral pathogenesis.
David
Live , Ph.D. Associate Research Scientist,
Complex Carbohydrate Research Center, University of Georgia, Athens, GA (USA) Subgroup(s): [Structural glycobiology, Glycans in immune recognition and function
, Glycan synthesis and microarrays
]
Research interests: Dr. Live's research involves characterizating the conformational properties of mucin glycoprotein motifs, with an emphasis on segments of mucin domains from cell surface components.
Timothy M.
Logan , Ph.D. Associate Professor,
Molecular Biophysics @ Florida State University, Tallahassee, FL (USA) Subgroup(s): [Glycans in cancer biology, Structural glycobiology]
Research interests: This group is studying how the protein and carbohydrate components of glycoproteins interact to generate the biologically functional molecule.
John
Lowe , M.D.[Associated Requests/Data] Henry Willson Payne Professor, Chair,
Department of Pathology @ Case Western Reserve University School of Medicine/University Hospitals, OH (USA) Subgroup(s): [Glycans in immune recognition and function
, Glycans in cancer biology]
Research interests: Dr. Lowe's research currently focuses on defining the functions of fucosylated and GalNAc-modified glycans in mammals. Specific areas of interest include understanding how fucosylation controls leukocyte adhesion and trafficking, how fucosylation controls signaling by the Notch family of cell surface signal transduction receptors, and how GalNAc modifications may control cell adhesion and signal transduction in the immune system.
Anice
Lowen , Ph.D.[Associated Requests/Data] Assistant Professor,
Emory University Subgroup(s): [To be Assigned]
Research interests: We study influenza virus transmission and aim to identify viral factors that impact the efficiency with which an influenza virus can spread from host-to-host.
Vladimir
Lugovtsev , Ph.D.[Associated Requests/Data] Scientist,
Center for Biologics Evaluation and Research @ FDA / DHHS, Bethesda, MD (USA) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory is studying the receptor-binding specificy of the influenza viruses in relation to the specific amino acid composition of the receptor-binding domain of the viral glycoprotein, hemagglutinin
Hiten
Madhani , Ph.D.[Associated Requests/Data] Profesor,
Department of Biochemistry and Biophysics @ University of California - San Francisco (USA) Subgroup(s): [To be Assigned]
Research interests: This laboratory focuses in human fungal pathgoen that secretes a polysaccharide capsule necessary for virulence
José M.
Mancheño , Ph.D.[Associated Requests/Data] Scientist,
Departamento de Cristalografía y Biología Estructural @ Instituto Subgroup(s): [Structural glycobiology, Glycans in host-microbe interactions]
Research interests: This laboratory is studying the determination at high resolution of the structural basis of the sugar-lectin interactions, mainly within the context of pore-forming toxins. In addition, we are exploring in detail the structure, function and folding of beta-trefoil lectin domains
Robert E.
Mandrell , Ph.D.[Associated Requests/Data] Research Leader,
Produce Safety and Microbiology Research @ USDA, Albany, CA (USA) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory focuses in the lipooligosaccharides (LOS) of different species of gram-negative bacterial pathogens that mimic antigenically and molecularly mammalian glycoconjugates
Rafael
Manez , M.D., Ph.D.[Associated Requests/Data] Professor,
Dept of Critical Care Medicine @ Bellvitge University Hospital, Barcelona (Spain) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory is focusing in the characterization of the target of xenoantibodies responsible for the acute rejection of pig organs transplanted in non-human primates after the continuous depletion of anti-galactosyl antibodies.
David
Margulies , MD, PhD[Associated Requests/Data] Senior Investigator, Senior Biomedical Research Service,
NIAID Subgroup(s): [To be Assigned]
Research interests:
Jamey D.
Marth , Ph.D.[Associated Requests/Data] Professor,
Burnham Institute for Medical Research, La Jolla, CA (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: Dr. Marth's laboratory is investigating the biological functions of glycan (sugar) molecules using genetic approaches in mammalian model systems. The laboratory is elucidating mechanisms by which the regulated expression of glycan linkages contribute to physiologic and disease processes.
Paul
Martin , Ph.D.[Associated Requests/Data] Associate Professor,
Department of Pediatrics and Neurology @Ohio State University , Columbus, OH (USA) Subgroup(s): [Glycans in development and physiology
]
Research interests: This laboratory studies the role of carbohydrates in the development of the nervous system and skeletal muscle, with particular focus on neuromuscular development and disease.
Mark
McClain , PhD[Associated Requests/Data] Research Assistant Professor,
Vanderbilt University Subgroup(s): [Glycans in host-microbe interactions]
Research interests: Studying the interactions between bacterial protein toxins and mammalian cells. These studies include work aimed at determining structure-function relationships, receptor characterization, and mammalian factors contributing to toxin activity.
Jon
McCullers , MD[Associated Requests/Data] Member,
St. Jude Children's Research Hospital Subgroup(s): [To be Assigned]
Research interests:
Rodger P.
McEver , M.D.[Associated Requests/Data] Member and Program Chair,
Cardiovascular Biology Research Program @ Oklahoma Medical Research Foundation, Oklahoma City, OK (USA) Adjunct Professor,
Department of Biochemistry and Molecular Biology @ University of Oklahoma Health Sciences Center (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: Dr. McEver's group studies selectin-glycoconjugate interactions in vitro and in vivo and biological functions of galectins.
John A.
McLean , Ph.D. [Associated Requests/Data] Assistant Professor,
Department of Chemistry @ Vanderbilt University, Nashville, TN (USA) Subgroup(s): [Glycomics and glycoinformatics]
Research interests: This laboratory focuses in the conceptualization, design, and construction of novel mass spectrometric instrumentation for biomolecular analyses.
Nancy A.
McNamara , Ph.D. [Associated Requests/Data] Assistant Professor,
Departments of Anatomy and Ophthalmology @ University of California - San Francisco (USA) Subgroup(s): [Glycomics and glycoinformatics]
Research interests: This laboratory is working to characterize the quantity and quality of goblet cell mucins in the mucosal epithelia of the lung and eye
Els
Meeusen , Ph.D.[Associated Requests/Data] Professor,
Biotechnology Research Laboratories @ Monash University, Clayton (Australia) Subgroup(s): [Glycans in cancer biology, Glycans in immune recognition and function
]
Research interests: This laboratory studies galectins from both parasites and their mammalian hosts, and their possible roles in allergic inflammation and parasite infection. This group also looks at the roles of (gal)lectins in innate immune responses to parasites/allergens.
Anand
Mehta , Ph.D. [Associated Requests/Data] Associate Professor,
Dept of Microbiology and Immunology @ Drexel Institute for Biotechnology and Virology Research, Doylestown, PA (USA) Subgroup(s): [To be Assigned]
Research interests:
Dale F.
Mierke , Ph.D. [Associated Requests/Data] Professor,
Department of Chemistry @ Dartmouth College, Hanover, NH (USA) Subgroup(s): [To be Assigned]
Research interests: This laboratory are interested in the structural characterization of protein interactions with cell surface exposed glycosylated targets.
Kenton S.
Miller , Ph.D.[Associated Requests/Data] Associate Professor,
Biology Department @ University of Tulsa, Tulsa, OK (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: Dr. Miller's laboratory is interested in the mechanisms controlling immune cell glycocalyx structure. The laboratory is currently focused on identifying extracellular signals which modulate cell surface sialylation and explicating their intracellular control pathways at the transcriptional, translational and post-translational levels.
Wayne
Mitzner , Ph.D. Professor and Director,
Division of Physiology @ Johns Hopkins University, Baltimore, MD (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory is concerned with mechanisms that underlie the chronic destruction of lung tissue in emphysema and fibrosis. Factors involved in the nonresolving inflammation in these diseases are the focus of experimental studies in mouse models.
Atsushi
Mizoguchi , M.D., Ph.D.[Associated Requests/Data] Assistant Immunologist and Instructor,
Immunopathology Unit @ Massachusetts General Hospital, Boston, MA (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: Dr. Mizoguchi's major research interest is in mucosal immunity associated with intestinal inflammation. This laboratory's current research has focused on studies to define the role of intestinal endogenous lectins, especially galectin-4, in the pathogenesis of intestinal inflammation observed in murine models of inflammatory bowel disease.
D. Branch
Moody , M.D. Assistant Professor,
Brigham and Women's Hospital, Boston, MA (USA) Subgroup(s): [Glycomics and glycoinformatics, Glycans in immune recognition and function
]
Research interests: Dr. Moody's laboratory studies the cellular and molecular mechanisms by which CD1 antigen presenting molecules bind lipid antigens and present them to T cells. In particular, this laboratory focuses on identifying new lipid antigens for T cells and understanding the molecular basis for their loading into the antigen binding grooves of CD1 proteins.
Tara
Moriarty , PhD[Associated Requests/Data] Assistant Professor,
University of Toronto Subgroup(s): [Glycans in host-microbe interactions]
Research interests: We study the mechanism of vascular adhesion under fluid shear force of the Lyme disease pathogen Borrelia burgdorferi. Using competitive inhibition approaches, we have determined that Borrelia vascular adhesion in vivo is dependent on glycosaminoglycans and a GAG-binding bacterial protein, BBK32, which is conserved in other bacterial pathogens. The identity of the glycosylated structures and host receptors targeted by BBK32 is unknown. As part of our characterization of the BBK32-regulated vascular adhesion mechanism, we would like to identify the glycosylated structures recognized by BBK32, in an effort to understand how this lectin mediates adhesion under shear force.
Sherie L.
Morrison , Ph.D. Professor,
Dept. of Microbiology, Immunology and Molecular Genetics @ UCLA, Los Angeles, CA (USA) Subgroup(s): [Glycans in cancer biology, Structural glycobiology]
Research interests: This laboratory focuses on the role of glycosylation in the biosynthesis and function of antibody molecules.
James P.
Nataro , M.D., Ph.D.[Associated Requests/Data] Professor,
Center for Vaccine Development @ University of Maryland School of Medicine, Baltimore, MD (USA) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory studies the interactions of enteric bacterial pathogens with the intestinal mucosa. In particular, the lab addresses the molecular interactions between bacterial protein adhesins and their glycoprotein receptors. These interactions are surprisingly dynamic and responsive, including such physiologic responses and signal transduction, cytokine release, opening of mucosal tight junctions and cell death
David S.
Newburg , Ph.D. Professor,
Department of Biochemistry and Molecular Pharmacology @ University of Massachusets Medical School, Waltham, MA (USA) Subgroup(s): [Glycan synthesis and microarrays
, Glycans in host-microbe interactions, Glycans in immune recognition and function
]
Research interests: This laboratory is studying the mechanisms whereby pathogen adhesins bind to cell surface glycans, and in the genetic basis for heterogenous expression of cell surface glycoconjugates and how that relates to individual susceptability to specific pathogens.
Olivier
Neyrolles , Ph.D.[Associated Requests/Data] Assistant Professor,
Institut Pasteur, Paris (France) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory focuses in the role of several C-type lectins of the SIGN family in immune response and pathology during Mycobacterium tuberculosis infection.
Lars
Nitschke , Ph.D.[Associated Requests/Data] Professor,
Institute for Genetic, University Erlangen-Nornberg (Germany) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: The focus of this laboratory is to study and identify the main ligand(s) for CD22 (Siglec-2), an adhesion receptor for a2,6-linked sialic acid, on the B cell surface.
Michel
Nussenzweig , M.D., Ph.D. Professor,
HHMI The Rockefeller University, New York, NY (USA) Subgroup(s): [To be Assigned]
Research interests: This group is studying lectins and mouse KOs for MMR and DEC205.
Josiah
Ochieng , Ph.D.[Associated Requests/Data] Professor,
Dept of Cancer Biology @ Meharry Medical College, Nashville, TN (USA) Subgroup(s): [Glycans in cancer biology]
Research interests: Dr. Ochieng's laboratory is very interested in understanding the extracellular functions of galectin-3, particularly regarding its role in the regulation of cellular adhesion. Cell biological as well as biochemical approaches are being used to dissect the role of this lectin in diverse extracellular functions with implications in cancer metastasis.
Thandi M.
Onami , Ph.D.[Associated Requests/Data] Assistant Professor,
Department of Microbiology @ University of Tennessee, Knoxville, TN (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory is interested in how glycosylation changes during memory T cell differentiation influence T cell effector function, homeostasis, and immune control following viral challenge.
Mario
Ostrowski , MD Associate Professor,
University of Toronto Subgroup(s): [To be Assigned]
Research interests: This investigator studies HIV immunology, pathogenesis and vaccine development. He is interested in looking at interactions between gp120, its related glycosylation residues and how they participate in pathogenesis, in particular, B cell and pDC cell activation and suppression.
Simone
Ottonello , Ph.D.[Associated Requests/Data] Professor,
Department of Biochemistry and Molecular Biology @ University of Parma (Italy) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This group is studying structural homologs of the bacterial lectin Cyanovirin-N, named CVNHs. CVNHs are small-size proteins (11 kDa) present in ascomycetous multicellular fungi and in ferns, whose biological role (including sugar binding ability and specificity) is as yet unknown.
Vladislav M.
Panin , Ph.D. Assistant Professor,
Department of Biochemistry and Biophysics @ Texas A&M University, College Station, TX (USA) Subgroup(s): [Glycans in development and physiology
, Structural glycobiology, Glycomics and glycoinformatics]
Research interests: This laboratory uses Drosophila model system to elucidate the role of glycosylation in metazoan development. The current research focuses on two evolutionary conserved glycosylation pathways, sialylation and O-mannosylation, both playing important biological roles in a wide range of organisms, from Drosophila to humans.
Noorjahan
Panjwani , Ph.D.[Associated Requests/Data] Professor,
Department of Ophthalmology and Biochemistry @ Tufts University School of Medicine, Boston, MA (USA) Subgroup(s): [Glycans in immune recognition and function
, Glycans in host-microbe interactions, Glycomics and glycoinformatics]
Research interests: Dr. Panjwani's laboratory is focusing on the mechanism by which galectins-3 and 7 mediate corneal epithelial cell migration. We are currently performing studies to: (i) identify and characterize the corneal epithelial cell surface and extracellular matrix (ECM) molecules which serve as counterreceptors of galectin-3 and -7, to establish whether the lectins modulate corneal epithelial cell migration by binding to well known integrins, growth factor receptors, and/or ECM molecules and (ii) determine whether galectin-3 mediates corneal epithelial cell migration indirectly by modulating the expression of key adhesion and/or signal transduction molecules by using small interfering RNA, cDNA microarrays and glycogene arrays.
Silvana
Papagerakis , M.D., Ph.D.[Associated Requests/Data] Assistant Professor,
Dept of Otolaryngology @ University of Michigan, Ann Arbor, MI (USA) Subgroup(s): [Glycans in cancer biology]
Research interests: This laboratory is focused on the roles of Sialyl-Lewis-x and E-selectin in the metastasis of oral cancers. Specifically: (1) identifying those glycosyltransferases involved in selectin ligand construction. (2) Determining the roles of chemokines in tethering and extravasation. (3) Identifying cytokines responsible for the expression of E-selectin and their source. Understanding the process of ligand construction and extravasation will identify points for clinical intervention.
John S.
Parker , Ph.D.[Associated Requests/Data] Assistant Professor,
Cornell University, Ithaca, New York (USA) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory is interested in the role that cell surface binding of glycans and other molecules plays in the tropism and virulence of feline calicviruses.
Manish S.
Patankar , Ph.D. Assistant Professor,
Dept of Obstetrics and Gynecology @ University of Wisconsin-Madison, Madison, WI (USA) Subgroup(s): [Glycans in immune recognition and function
, Glycans in cancer biology]
Research interests: This laboratory focuses in defining the immunomodulating roles of glycoproteins in human pregnancy, benign gynecologic conditions, and in epithelial ovarian tumors.
Adrienne W.
Paton , Ph.D. Senior Research Officer,
University of Adelaide (Australia) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory focuses on mechanisms of bacterial pathogenesis and the
interactions between bacterial virulence factors and host
glycoconjugates
James C.
Paton , Ph.D. [Associated Requests/Data] Professor,
School of Molecular and Biomedical Science, University of Adelaide (Australia) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory focuses on mechanisms of bacterial pathogenesis and the
interactions between bacterial virulence factors and host
glycoconjugates
James
Paulson , Ph.D.[Associated Requests/Data] Professor,
Dept of Chemical Physiology & Molecular Biology @ The Scripps Research Institute, La Jolla, CA (USA) Subgroup(s): [Glycans in immune recognition and function
, Glycan synthesis and microarrays
]
Research interests: Dr. Paulson's group investigates the roles of carbohydrate-binding proteins involved in immune regulation and human disease, through their interaction with carbohydrate groups expressed on cell surface glycoconjugates. This laboratory is currently focused on how sialoside ligands modulate Siglec functions and on understanding the molecular basis of glycosylation changes following differentiation and activation of leukocytes.
Julie K.
Pfeiffer , Ph.D. Assistant Professor,
Department of Microbiology @ University of Texas Southwestern Medical Center, Dallas, TX (USA) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory is focusing on defining the specificity of polysaccharide:virus interactions
J. Michael
Pierce , Ph.D.[Associated Requests/Data] Professor,
Dept. of Biochemistry and Molecular Biology, Complex Carbohydrate Research Center @ University of Georgia, Athens, GA (USA) Subgroup(s): [Glycans in cancer biology]
Research interests: Dr. Pierce's laboratory is focused on understanding how glycoconjugates regulate cell adhesion, particularly during oncogenesis and tumor progression.
Seth
Pincus , M.D.[Associated Requests/Data] Professor,
Department of Microbiology, Immunology and Parasitolog @ Research Institute for Children, New Orleans, LA (USA) Subgroup(s): [Glycans in host-microbe interactions, Glycans in immune recognition and function
]
Research interests: This laboratory is studying the capsular polysaccharide of the pathogenic bacterium group B streptococcus. We are interested in interactions of antibody with the capsule: how antibody protects against infection, how anti-capsular antibody may be induced by vaccines, and how the capsule functions in disease pathogenesis.
Steven A.
Porcelli , M.D. Professor,
Department of Microbiology and Immunology @ Albert Einstein College of Medicine, Bronx, NY (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: A major focus of this laboratory is the identification and characterization of glycolipid ligands for CD1 molecules and the recognition of these by CD1-restricted T cells. This laboratory is assessing the role of T-cell recognition of glycolipids in bacterial infections, and in the generation and control of autoimmunity.
Matteo
Porotto , Ph.D.[Associated Requests/Data] Assistant Professor,
Cornell University, Joan and Sanford I. Weill Medical College, New York, NY (USA) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory focuses in the role of the parainfluenza virus receptor-binding protein hemagglutinin-neuraminidase (HN).
Nicholas
Provart , Ph.D.[Associated Requests/Data] Associate Professor,
Department of Cell & Systems Biology @ University of Toronto (Canada) Subgroup(s): [To be Assigned]
Research interests: plant glycan-binding proteins
Suzie
Pun , PhD Associate Professor,
University of Washington Subgroup(s): [To be Assigned]
Research interests: The focus of the research in my lab is the delivery of biologics (i.e. dna, peptides, proteins) via viral vectors, synthetic polymeric vectors, and polymer-virus hybrid vectors as well as targeted delivery of molecular imaging contrast agents for cancer detection. We have developed several sugar-based materials for delivery and cell targeting. I contributed toward the development of the first cyclodextrin-based polymers used in clinical trials for siRNA delivery [1,2]. We have also investigated the role of particle size in galactose-mediated nanoparticle targeting to hepatocytes [3,4]. In gene delivery studies, we have shown the critical role of heparan sulfate proteoglycans (HSPGs) for mediating cell uptake of polymer-coated adenovirus for transduction [5]. For cancer detection projects, glycan targets have been identified as potential biomarkers for identification of precancerous tissue in the esophagus [work in progress]. Thus, my lab has come to appreciate the importance of glycans in mediating biological processes, and we intend to further study these mechanisms in order to engineer more effective vectors for gene delivery and cancer detection. The CFG houses a valuable number of resources such as glycan array screenings and the reagent bank that can further this research.
Ronald T.
Raines , Ph.D.[Associated Requests/Data] Professor,
Departments of Biochemistry and Chemistry @ University of Wisconsin - Madison, WI (USA) Subgroup(s): [Glycans in cancer biology]
Research interests: This laboratory is focusing on the cell-surface carbohydrates that are recognized by secretory ribonucleases.
Olof
Ramstrom , Ph.D. Associate Professor,
Dept of Chemistry, Organic Chemistry @ Royal Institute of Technology, Stockholm (Sweden) Subgroup(s): [Glycan synthesis and microarrays
]
Research interests: This laboratory focuses in the design and fabrication of carbohydrate
microarrays and the synthesis of carbohydrates and neoglycoconjugates. It is
also involved in investigations on the molecular basis of carbohydrate
recognition by animal and plant lectins.
Avraham
Raz , Ph.D.[Associated Requests/Data] Professor,
Pathology, Radiation Oncology, Oncology @ Wayne State University, School of Medicine, Detroit, MI (USA) Subgroup(s): [Glycans in cancer biology]
Research interests: This laboratory's current research interest is in unveiling the role of galectin-3 in metastasis, specifically as it relates to apoptosis resistance during cancer progression. These studies should advance the understanding of carbohydrate-protein interactions and the structural motifs involved in such a process.
CelsoA.
Reis , Ph.D.[Associated Requests/Data] Senior Researcher,
Institute of Molecular Pathology and Immunology of the University of Porto, (Portugal) Subgroup(s): [Glycans in host-microbe interactions, Glycans in cancer biology]
Research interests: This group is focusing on the molecular mechanisms of the biosynthesis of glycoconjugates and carbohydrate ligands important in the process of gastric carcinogenesis and on gastric carcinoma progression and metastasis.
Risto
Renkonen , M.D.[Associated Requests/Data] Acting Chair,
Department of Bacterial & Immunology @ University of Helsinki, Helsinki (Finland) Professor,
Department of Immunology @ University of Helsinki, Helsinki (Finland) Subgroup(s): [Glycans in immune recognition and function
, Glycans in host-microbe interactions, Glycomics and glycoinformatics]
Research interests: This laboratory is analyzing organ-specific leukocyte trafficking. This includes the detailed analysis on endothelial glycoproteins such as CD34 from various normal and inflammed organs and also the development of techniques for the non-invasive in vivo techniques for the analysis of leukocyte extravasation in human patients.
Nicholas
Roberts , Ph.D.[Associated Requests/Data] Research Scientist and Project Leader,
AgResearch Grasslands Research Centre (New Zealand) Subgroup(s): [To be Assigned]
Research interests: This laboratory focuses in the structure/function relationships of soluble apyrases; in particular their carbohydrate binding properties.
Maria-Cristina
Roque-Barreira , M.D., Ph.D.[Associated Requests/Data] Professor,
Dept of Parasitology, Microbiology and Immunology @ Faculty of Medicine of Ribeirao Preto, University of Sao Paulo (Brazil) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory focuses in the biological activities of mammal, plant and
microbial lectins, with emphasis on the immune response to infection.
David
Rose , null[Associated Requests/Data] Professor,
University of Waterloo Subgroup(s): [To be Assigned]
Research interests:
Steven
Rosen , Ph.D.[Associated Requests/Data] Professor,
Department of Anatomy @ University of California San Francisco, CA (USA) Subgroup(s): [Glycans in cancer biology, Glycans in immune recognition and function
]
Research interests: This laboratory works on selectins and their carbohydrate ligands in lymphocyte homing and inflammation. The lab also studies heparin-degrading endosulfatases and their roles in regulating the interactions of growth factors and morphogens with proteoglycans.
Jamie
Rossjohn , Ph.D.[Associated Requests/Data] Professor,
Department of Biochemistry and Molecular Biology @ Monash University, Victoria (Australia) Subgroup(s): [To be Assigned]
Research interests: This laboratory is focusing on infection and immunity, and many of the receptors require specific glycans to mediate their effects.
Charles J.
Russell , Ph.D.[Associated Requests/Data] Assistant Member,
Infectious Diseases @ St. Jude Children's Research Hospital, Memphis, TN (USA) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory is studying the receptor-binding specificities and affinities of influenza virus and paramyxovirus envelope glycoproteins.
Gustaf
Rydell , PhD Researcher,
Chalmers University of Technology Subgroup(s): [To be Assigned]
Research interests: Focused on norovirus-carbohydrate interactions. Norovirus is a non-enveloped virus and as mentioned on the CFG Paradigm pages, the binding specificity is important for the tropism and pathogenicity of different viruses within the norovirus family. I want to determine the precise functions of the different carbohydrate binding specificities of noroviruses.
Subash
Sad , Ph.D.[Associated Requests/Data] Staff Scientist,
National Research Council of Canada, Ottawa, Ontario (Canada) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This group is studying antigen-presentation, T cell memory generation and memory maintenance against various intracellular pathogens in vivo. The group uses transgenic T cells of defined antigenic specificity and recombinant intracellular pathogens expressing a defined antigen.
Sachiko
Sato , Ph.D.[Associated Requests/Data] Associate Professor,
Faculty of Medicine @ Laval University, Quebec (Canada) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory has been investigating roles of galectins as immunomodulators in innate immune responses to infectious diseases. Particularly, roles of galectins as leukocyte adhesion modulators in the extravasation and roles of galectins as immunomodulators in the pathogenesis of parasitic infections are our main interests.
Harry
Schachter , M.D., Ph.D., F.R.S.C. Scientist Emeritus,
The Hospital for Sick Children Research Institute, Toronto (Canada) Professor Emeritus,
Dept. of Biochemistry @ University of Toronto, Toronto (Canada) Subgroup(s): [Glycans in development and physiology
]
Research interests: Dr. Schachter's laboratory is interested in using Caenorhabditis elegans and Drosophila melanogaster as model organisms to develop a functional post-translational proteomics approach to study the role of N-glycans in eukaryote development. Since this is a very difficult problem, Dr. Schachter joined the Consortium to discuss ideas on how to approach this problem.
Peer
Schenk , Ph.D. [Associated Requests/Data] Senior Lecturer,
Biological Sciences @ The University of Queensland, Brisbane (Australia) Subgroup(s): [To be Assigned]
Research interests: This laboratory is focused in the study beneficial and parasitic interactions of plants with microbes
Todd
Schlenke , Ph.D.[Associated Requests/Data] Assistant Professor,
Biology @ Emory University, Atlanta, GA (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: his laboratory is focusing on the innate immune system of Drosophla melanogaster, and in particular how flies can distinguish their own tissues from those of metazoan pathogens such as parasitic wasps.
Brigitte
Schmitz , Ph.D.[Associated Requests/Data] Professor,
Department Biochemistry @ University of Bonn, Institute of Physiology, Biochemistry and Hygienics of Animals (Germany) Subgroup(s): [Structural glycobiology, Glycans in development and physiology
]
Research interests: The project is aimed at understanding the role of the Lex-containing L5 carbohydrate epitope in the developmental process of neural induction. We plan to identify 1) the protein to which the L5 glycan is attached, 2) glycosyltransferases upregulated during neural induction, 3) the corresponding L5 carbohydrate binding protein (CBP), 4) the mechanism of interaction between L5 and its CBP, and 5) the spatiotemporal regulation of L5 and L5-CBP expression during neural induction.
Ronald L.
Schnaar , Ph.D.[Associated Requests/Data] Professor,
Department of Pharmacology @ The Johns Hopkins School of Medicine, Baltimore, MD (USA) Subgroup(s): [Glycans in development and physiology
, Glycans in immune recognition and function
]
Research interests: In the focus area of neuroglycobiology, we study the functions of myelin-associated glycoprotein (Siglec-4), which binds to brain gangliosides to mediate axon-myelin stability and modulate nerve regeneration. We are also probing human leukocyte gangliosides as the endogenous ligands that mediate E-selectin dependent tethering and rolling during inflammation.
Nathalie
Scholler , M.D., Ph.D.[Associated Requests/Data] Assistant Professor,
Immunology / Recombinant Antibody Engineering @ University of Pennsylvania, Philadelphia, PA (USA) Subgroup(s): [Glycans in immune recognition and function
, Glycans in cancer biology, ]
Research interests: This laboratory studies the role of innate immunity in ovarian cancer, and in particular the roles of mannose receptor and complement factors. We also develop libraries of yeast-expressed affinity reagents for early diagnostic and therapy of cancer.
John
Schrader , Ph.D.[Associated Requests/Data] Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory studying the structure-function relationships and genetic origins of a structural family of human antibodies that neutralize infectivity of the common pathogen human cytomegalovirus (HCMV ) by binding to a defined peptide epitope on the viral envelope glycoprotein gB.
Stacey
Schultz-Cherry , Ph.D.[Associated Requests/Data] Associate Member,
Dept. of Infectious Diseases @ St Jude Children's Research Hospital, Memphis, TN (USA) Subgroup(s): [To be Assigned]
Research interests: This laboratory is focusing on the viral-cellular interactions in differentiated primary human and animal/avian bronchial epithelial cells and intestinal cells
Gerald (Gary)
Schwarting , Ph.D.[Associated Requests/Data] Professor,
Department of Cell Biology @ University of Massachusetts Medical School, Waltham, MA (USA) Subgroup(s): [Glycans in development and physiology
]
Research interests: Dr. Schwarting's research is focused on the analysis of developmentally regulated cell surface molecules and their role in axon guidance and neuronal migration, using the olfactory system as a model. The interaction of cell surface glycans with endogenous lectins in the extracellular matrix provides one mechanism by which axons can utilize specific pathways as they grow towards their targets.
Dorothy
Scott , M.D. [Associated Requests/Data] Supervisory Medical Officer and Branch Chief,
U.S. Food and Drug Administration, Bethesda, MD (USA) Subgroup(s): [Glycans in immune recognition and function
, Glycans in host-microbe interactions]
Research interests: This laboratory focuses to develop methods that can be used for rapid screening of hyperimmune plasma from donors vaccinated against pandemic and epidemic influenza strains.
Cynthia
Sears , M.D. [Associated Requests/Data] Professor,
Divisions of Infectious Diseases and Gastroenterology @ Johns Hopkins University, Bethesda, MD (USA) Subgroup(s): [To be Assigned]
Research interests: This laboratory is studying on understand how enterotoxigenic Bacteroides fragilis (ETBF), a cause of human diarrheal disease and a suspected initiator of human colitis and colorectal cancer
Verena
Seidl-Seiboth , Ph.D. Head of Project Group,
Gene Technology and Applied Biochemistry @ Vienna University of Technology, Vienna (Austria) Subgroup(s): [To be Assigned]
Research interests: This laboratory is focused on the properties of carbohydrate-binding proteins and carbohydrate-active enzymes in fungi. In particular, we are interested in the regulation and biochemistry of fungal cell wall degradation during the fungal life cycle.
Jin-Xiong
She , PhD[Associated Requests/Data] Director,
Center for Biotechnology and Genomic Medicine, Georgia Regents University Subgroup(s): [To be Assigned]
Research interests: Diabetes
Protul A.
Shrikant , Ph.D. Assistant Professor,
Department of Immunology @ Roswell Park Cancer Institute, Buffalo, NY (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: The research in this laboratory is focused on understanding the basis for CD8+ T cell tolerance and immunity to tumors. The projects pursued include 1) sialyl-glycan mediated regulation of CD8+ T cell responses to tumor-antigens and 2) generating cytokine therapies for T cell immunity to cancer.
Peter
Sieling , Ph.D. Associate Professor,
Division of Dermatology, Department of Medicine @ The David Geffen School of Medicine at UCLA, Los Angeles, CA (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: Dr. Sieling's group investigates the role of human CD1-restricted T cells in the immune response to microbial infection with particular emphasis on mycobacterial diseases including leprosy and tuberculosis. We have also identified human CD1-restricted T cells against gram negative bacteria.
Paul
Sieving , null[Associated Requests/Data] Scientist,
NIH Subgroup(s): [To be Assigned]
Research interests:
Anna
Simon , Ph.D.[Associated Requests/Data] Independent Investigator,
Human Immunology Unit MRC @ University of Oxford (United Kingdom) Subgroup(s): [Glycans in immune recognition and function
, Glycans in cancer biology]
Research interests: The laboratory focuses on the generation of monoclonal antibodies against the murine tumour cell line B16F10. One of the antibodies rejecting B16F10 in vivo is likely to recognise a carbohydrate structure which we are keen to identify. Other antibodies might recognise other carbohydrate structures.
Pradhyumna Kumar
Singh , Ph.D. Scientist,
Plant Molecular Biology Division @ National Botanical Research Institute (India) Subgroup(s): [To be Assigned]
Research interests: This laboratory is focused in isolation of novel lectin having insecticidal activity
Jatinder
Singh , Ph.D. Consultant,
Aravind Eye Hospital & PostGraduate Institute of Ophthalmology (India) Subgroup(s): [To be Assigned]
Research interests:
Gary
Siuzdak , Ph.D.[Associated Requests/Data] Associate Professor,
Center for Mass Spectrometry @ The Scripps Research Institute, La Jolla, CA (USA) Subgroup(s): [Glycomics and glycoinformatics]
Research interests: This laboratory is optimizing desorption/ionization on silicon mass spectrometry technology for the characterization of carbohydrates
David F.
Smith , Ph.D.[Associated Requests/Data] Professor,
Emory University, Atlanta, GA (USA) Subgroup(s): [Glycans in host-microbe interactions, Glycomics and glycoinformatics, Structural glycobiology, Glycan synthesis and microarrays
, Glycans in immune recognition and function
]
Research interests: This laboratory is focusing in a new glycomic approach termed “Shotgun Glycomics” to link glycan structure to function using our new technology that allows us to fluorescent tag free glycans released from specific cell or tissue glycoconjugates, separate them by chromatographic methods to obtain tissue- and/or cell-specific tagged-glycan libraries (TGLs). The tagged glycans retain a functional group to allow covalent “printing” of these libraries as microarrays that are subsequently interrogated with glycan binding proteins (GBPs), pathogens, and cells to identify functionally recognized and biologically significant glycans for structural definition.
Frances
Smith , Ph.D.[Associated Requests/Data] Associate Professor,
Dept of Psychiatry @ University of Massachussetts Medical School, Waltham, MA (USA) Subgroup(s): [To be Assigned]
Research interests: This laboratory studies the role of carbohydrates in the development of the central nervous system.
Karen R.
Snapp , Ph.D. Assistant Professor,
Department of Pharmacology @ University of Illinois at Chicago, Chicago, IL (USA) Subgroup(s): [Glycans in immune recognition and function
, Glycans in host-microbe interactions]
Research interests: This laboratory is investigating the structural and biochemical modifications of PSGL-1 required for functional interactions with P- and L-selectin. We are also studying the role of PSGL-1 as the entry receptor for Anaplasma phagocytophila, the causative agent of Human Granulocytic Ehrlichiosis (HGE). In addition, we are investigating the role that carbohydrates play in crosstalk between endothelial selectins and their leukocyte carbohydrate ligands.
Thomas E.
Spencer , Ph.D.[Associated Requests/Data] Associate Professor,
Center for Animal Biotechnology and Genomics @ Texas A&M University, College Station, TX (USA) Subgroup(s): [Glycans in development and physiology
]
Research interests: This laboratory focuses on the biochemical aspects of conceptus-endometrial interactions during the implantation period of pregnancy.
Pragada
Sriramarao , Ph.D.[Associated Requests/Data] Associate Dean for Research and Professor,
Dept of Vet & Biomedical Sciences @ University of Minnesota, St. Paul, MN (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This group is studying the role of carbohydrates in allergic inflammation - specifically, how these molecules support eosinophil trafficking in blood vessels.
Miguel
Stadecker , MD, PhD[Associated Requests/Data] Professor,
Tufts University Subgroup(s): [To be Assigned]
Research interests: Schistosomiasis
Nicholas M.
Stamatos , M.D., Ph.D.[Associated Requests/Data] Assistant Professor,
DIvision of Infectious DIseases, Institute of Human Virology @ University of Maryland Medical, Baltimore, MD (USA) Subgroup(s): [To be Assigned]
Research interests: This group focuses in determining how modulation of the sialic acid content of glycoconjugates on the surface of cells of the immune system influences cell function
Pamela
Stanley , Ph.D.[Associated Requests/Data] Professor,
Department of Cell Biology @ Albert Einstein College of Medicine, Bronx, NY (USA) Subgroup(s): [Glycans in cancer biology, Glycans in development and physiology
]
Research interests: Dr. Stanley's laboratory is interested in 1) understanding the biological roles of specific classes of N-glycan in development and immunity through studies of glycosyltransferase mutant mice, 2) identifying complex binding specificities of galectins using a panel of CHO glycosylation mutants, and 3) determining how O-fucose glycans function in Notch receptor signaling and in modulating the interaction of Notch receptors with their ligands.
Chad
Steele , Ph.D. Associate Professor,
Departments of Medicine and Microbiology @ University of Alabama, Birmingham, AL (USA) Subgroup(s): [To be Assigned]
Research interests: This laboratory studies the role of the Dectin-1 beta-glucan receptor in recognizing and reacting to pathogenic fungal organisms.
David
Stein , Ph.D.[Associated Requests/Data] Associate Professor,
Department of Molecular Cell and Developmental Biology @ University of Texas at Austin, Austin, Texas (USA) Subgroup(s): [Glycans in development and physiology
]
Research interests: This laboratory is investigating the involvement of protein glycosylation and oligosaccharide sulfation in the establishment of Drosophila embryonic Dorsal-Ventral polarity.
Richard L.
Stevens , Ph.D. Professor,
Brigham and Women's Hospital, Harvard School of Medicine, Boston, MA (USA) Subgroup(s): [To be Assigned]
Research interests: This laboratory studies on the serglycin family of proteoglycans that are stored in the secretory granules of mast cells (MCs) and other immune cells.
Lloyd M
Stoolman , M.D.[Associated Requests/Data] Professor,
Department of Pathology, University of Michigan, Ann Arbor, MI (USA) Subgroup(s): [To be Assigned]
Research interests: This laboratory focuses on selectin mediated recruitment during adoptive immunotherapy for metastatic cancer.
Richard
Strasser , Ph.D.[Associated Requests/Data] Assistant Professor,
Institute for Applied Genetics and Cell Biology, University of Natural Resources and Applied Life Sciences, Vienna (Austria) Subgroup(s): [Structural glycobiology, Glycans in development and physiology
]
Research interests: This laboratory focuses on enzymes (glycosidases and glycosyltransferases) involved in the biosynthesis and processing of plant N-glycans and investigates the pyhsiological function of plant N-glycans.
Kaihong
Su , PhD Associate Professor,
University of Nebraska Subgroup(s): [Glycan synthesis and microarrays
, Glycans in cancer biology, Glycans in immune recognition and function
]
Research interests: Current research is focused on the molecular mechanisms of autoimmune diseases, mainly systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) and the identification of disease biomarkers and therapeutic pathways for SLE and RA.
Paul M.
Sullam , M.D. [Associated Requests/Data] Professor,
Department of Medicine, University of California, San Francisco & VA Medical Center (USA) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: his laboratory focuses on the mechanisms for microbial binding to human proteins, as mediated by a newly-recognized family of bacterial surface glycoproteins
Geoffrey
Swanson , Ph.D. Associate Professor,
Northwestern Subgroup(s): [To be Assigned]
Research interests: The role of galectins in the mammalian CNS, and a
more generalized interest in the role of neuronal glycobiology in physiology and pathology
Christine M.
Szymanski , Ph.D.[Associated Requests/Data] Associate Professor,
Department of Biological Sciences @ University of Alberta, Edmonton, Alberta (Canada) Subgroup(s): [Glycans in immune recognition and function
, Glycans in host-microbe interactions, Structural glycobiology]
Research interests: This laboratory investigates bacterial N-linked glycoprotein pathways and their influence on the host. We also exploit these glycosylation pathways to generate glycoconjugate vaccines, develop new methods to study these systems, and try to understand the influence of bacterial viruses on glycan variability and bacterial evolution.
Ming
Tan , PhD[Associated Requests/Data] Assistant Professor,
Cincinnati Children's Hospital Medical Center Subgroup(s): [To be Assigned]
Research interests: Study of the specific interaction between enteric viruses and
carbohydrates and their functional significance in virus infection.
Rusung
Tan , M.D., Ph.D. Professor,
Department of Pathology & Laboratory Medicine @ University of British Columbia, Vancouver (Canada) Subgroup(s): [To be Assigned]
Research interests: This laboratory is focusing on the function of a protein, CLEC16A, a C-type lectin which may have oligosaccharide ligand(s).
Haixu
Tang , Ph.D. Assistant Professor,
Indiana University, Bloomington, IN (USA) Subgroup(s): [Glycomics and glycoinformatics]
Research interests: This group is focusing in developing algorithms for interpreting the MS/MS spectra of glycans and glycopeptides. They are also interested in developing computational methods to quantify glycans using MALDI-MS.
Nongnuj
Tanphaichitr , Ph.D. Senior Scientist,
Obstetrics and Gynecology and Biochemistry/Microbiology/Immunology, Ottawa Health Research Institute, Ontario (Canada) Professor,
University of Ottawa, Ontario (Canada) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: Dr. Tanphaichit's group is focused on discerning the molecular mechanisms through which mammalian sperm interact with the egg zona pellucida. For the past 16 years, we have looked closely into the roles of the male germ cell-specific sulfoglycolipid (sulfogalactosylglycerolipid-SGG, also known as seminolipid) and its binding protein, arylsulfatase A (which also exists on the sperm surface), in this sperm-egg interaction.
Joyce
Taylor-Papadimitriou , Ph.D.[Associated Requests/Data] Professor,
ICRF Breast Cancer Biology Group @ Imperial Cancer Research Fund, King's College London (UK) Subgroup(s): [Glycans in cancer biology, Glycans in immune recognition and function
]
Research interests: This laboratory focuses on defining the changes in the phenotype of breast epithelial cells which occur in human breast cancer. Particular emphasis is given to understanding the effects of changes in mucin type O-glycosylation on tumour associated antigens and their interactions with immune effector cells.
Thor
Theander , Ph.D.[Associated Requests/Data] Professor,
Immunology Medical microbiology @ University of Copenhagen (Denmark) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory is focus on defining the binding phenotypes of Plasmodium falciparum erythrocyte membrane protein 1 (PfEMP1) variants associated with severe malaria in children.
Victor LJL
Thijssen , Ph.D. [Associated Requests/Data] Assistant professor,
Dept of Radiotherapy @ VU University Medical Center (The Netherlands) Subgroup(s): [Glycans in cancer biology]
Research interests: This laboratory focuses on the role of galectins in endothelial cell biology and developing galectin targeting molecules for the diagnosis and treatment of cancer.
Hung
Ton-That , Ph.D.[Associated Requests/Data] Associate Professor,
Department of Microbiology & Molecular Genetics @ University of Texas-Houston Medical School, Houston, TX (USA) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory is focused on dissect the molecular interactions between Actinomyces fimbriae and glycan receptors present on the surface of host cells and oral streptococci
Tzuen-Rong
Tzeng , Ph.D.[Associated Requests/Data] Assistant Professor,
Clemson University, Clemson, SC (USA) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory is focusing on the interaction between microbial pathogens and host cells, specifically via the lectin-ligand interactions, for applications in disease prevention and treatment as well as biosensor development.
Irma
Van Die , Ph.D.[Associated Requests/Data] Associate Professor,
Department of Molecular Cell Biology, Glycoimmunology Group @ VU University Medical Center, Amsterdam (The Netherlands) Subgroup(s): [Glycans in host-microbe interactions, Glycan synthesis and microarrays
, Glycans in immune recognition and function
]
Research interests: 1) Molecular and functional characterization of glycan-lectin interactions involved in recognition of Schistosomes by immune cells, and 2) C-type lectin-carbohydrate interactions in cellular communication in the immune system and regulation of the biosynthesis of the glycan-ligands involved.
Willem
van Eden , null[Associated Requests/Data] Professor,
Utrecht University Subgroup(s): [To be Assigned]
Research interests:
Yvette
Van Kooyk , Ph.D.[Associated Requests/Data] Professor and Head,
Department of Molecular Cell Biology, DC Immunology Group @ Vrije University Medical Center, Amsterdam (The Netherlands) Subgroup(s): [Glycans in cancer biology, Glycans in immune recognition and function
]
Research interests: Dr. van Kooyk's laboratory is exploring the function of antigen presenting cells, such as dendritic cells (DC), that regulate viral-antigen recognition, DC trafficking and T cell binding--all processes that initiate immunity or tolerance. Essential in this is the recognition of ligands by C-type lectins and the functional consequences of differential terminal glycosylation that may regulate DC function.
David L.
Van Vactor , Ph.D. Associate Professor,
Dept. of Cell Biology, Harvard Medical School, Boston, MA (USA) Subgroup(s): [Glycans in development and physiology
]
Research interests: This laboratory studies the roles of heparan sulfate proteoglycans during nervous system development and evolution
Sandra J.
van Vliet , Ph.D. [Associated Requests/Data] Scientist,
Dept. of Molecular Cell Biology and Immunology @ VU University Medical Center, Amsterdam (the Netherlands) Subgroup(s): [Glycans in immune recognition and function
, Glycans in cancer biology]
Research interests: This laboratory is focus on the specific glycan structures on self-antigens or pathogens that are recognized by different C-type lectins and to understand how these interactions influence and control immune cell function.
Christoph
Wagener , Ph.D.[Associated Requests/Data] Director,
University Medical Center Hamburg-Eppendorf, Hamburg (Germany) Subgroup(s): [Glycans in cancer biology]
Research interests: This laboratory is focused on generates recombinant human glycoreceptors (C-type lectins) to characterize membrane glycoproteins of human cells in Far Western blots and subpopulations of human cells (tumor cells, blood cells) by flow cytometry.
Gabriel
Waksman , Ph.D.[Associated Requests/Data] Professor,
Department of Biochemistry and Molecular Biology @ University College-Birkbeck College, London (UK) Subgroup(s): [Structural glycobiology, Glycans in host-microbe interactions]
Research interests: This laboratory focuses in the structural biology of bacterial attachment and pilus biogenesis as well as more general protein secretion systems in Gram-negative bacteria such type IV and V secretion systems.
Yanzhuang
Wang , Ph.D. Asistant Professor,
Department of Molecular, Cellular and Developmental Biology @ University of Michigan, Ann Arbor, MI (USA) Subgroup(s): [To be Assigned]
Research interests: TThis laboratory is focusing on changes of protein glycosylation in cells with altered Golgi structure and function under physiological and pathological conditions
Lai-Xi
Wang , Ph.D. Associate Professor,
Institute of Human Virology @ University of Maryland, Baltimore, MD (USA) Subgroup(s): [Structural glycobiology]
Research interests: This laboratory is focused on the design and synthesis of novel glycoconjugates for addressing fundamental problems in glycobiology and biomedicine.
John L.
Wang , Ph.D. Professor,
Department of Biochemistry @ Michigan State University, East Lansing, MI (USA) Subgroup(s): [Glycans in immune recognition and function
, Structural glycobiology, Glycans in cancer biology]
Research interests: This laboratory is focused on the intracellular activities of galectin-1 and galectin-3. The specific objectives of the research include: (a) to delineate the role(s) galectins-1 and -3 play in nuclear pre-mRNA splicing; (b) to characterize the nuclear and cytoplasmic complexes with which galectin-1 and/or galectin-3 are associated; and (c) to analyze the mechanism and regulation of transport of the two proteins between the nuclear and cytoplasmic compartments.
Paula I.
Watnick , M.D., Ph.D[Associated Requests/Data] Assistant Professor,
Division of Infectious Diseases @ Children's Hospital Boston/Harvard Medical School (USA) Subgroup(s): [Glycans in immune recognition and function
, Glycans in host-microbe interactions]
Research interests: This laboratory is studying the protein and exopolysaccharide components of the Vibrio cholerae biofilm matrix and to understand how the matrix influences intercellular interactions between diverse bacteria and between V. cholerae and intestinal epithelial cells
Alison
Weiss , Ph.D.[Associated Requests/Data] Professor,
Molecular Genetics, Biochemistry and Microbiology @ University of Cincinnati, OH (USA) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory focuses in the interaction of bacterial toxins (pertussis toxin and Shiga toxin) with their mammalian glycan receptors
Zena
Werb , Ph.D. Professor,
Department of Anatomy @ University of California San Francisco (USA) Subgroup(s): [Glycans in development and physiology
, Glycans in cancer biology]
Research interests: This laboratory is studying the role of heparan sulfate proteoglacans in development and disease through the study of mice that are mutant for the hereditary exostosis genee (Ext2) and for the extracellular sulfatases Sulf-1 and Sulf-2.
Victoria
Werth , M.D.[Associated Requests/Data] Professor,
Dermatology and Medicine @ University of Pennsylvania, Philadelphia, PA (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory focuses in the area of inflammatory skin diseases, with a specific interest in extracellular matrix molecules in photoaging and autoimmune skin disease.
Martin K.
Wild , Ph.D.[Associated Requests/Data] Professor,
Department of Vascular Cell Biology @ Max-Planck-Institut for Molecular Biomedicine, Munster (Germany) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory is studying congenital disorders of glycosylation,
interactions of selectin and DC-SIGN-like molecules with their ligands,
nucleotide-sugar transporters, glycosyltransferases and leukocyte
trafficking.
Ronnie
Willaert , Ph.D.[Associated Requests/Data] Principal Investigator, visiting professor,
Vrije Universiteit Brussel Subgroup(s): [Glycans in host-microbe interactions, Structural glycobiology]
Research interests: Research is focussed on infectious yeast cells (Saccharomyces cerevisiae, Candida albicans and C. glabrata); specifically, adhesins/lectins are studied that interact with mammalian glycoproteins.
John V.
Williams , M.D.[Associated Requests/Data] Assistant Professor,
Division of Infectious Diseases @ Vanderbilt University, Nashville, TN (USA) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory is focus on the virus-host interface and particularly how protein-carbohydrate interactions mediate cell attachment, fusion and entry.
Hugh J.
Willison , Ph.D.[Associated Requests/Data] Professor,
Department of Neurology @ University of Glasgow, Glasgow (UK) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: Dr. Willison's laboratory focuses on protein-carbohydrate interactions, specifically those between immunoglobulins and carbohydrate structures, and the mechanisms by which these relate to nervous system autoimmunity.
Marsha
Wills-Karp , Ph.D.[Associated Requests/Data] Professor,
Department of Pediatrics @ University of Cincinnati College of Medicine, Cincinnati, Ohio (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory is studying the beta-glucan structures within house dust mite (HDM) and identify their role in innate immune airway responses.
Ian A.
Wilson , Ph.D.[Associated Requests/Data] Professor,
Department of Molecular Biology and Skaggs Institute for Chemical Biology @ The Scripps Research Institute, La Jolla, CA , Adjunct Professor, Department of Pathology, UCSD, La Jolla, CA (USA) Subgroup(s): [Structural glycobiology, Glycans in host-microbe interactions, Glycans in immune recognition and function
]
Research interests: The main focus of Dr. Wilson's group is on antigen recognition by the immune system. The specific topics include TCR-pMHC, antibody-antigen and TCR-CD1 interactions with particular reference to glycosylated antigens, presented by CD1 and MHC class I.
Paul
Winyard , Ph.D.[Associated Requests/Data] Senior Lecturer,
Department of Nephro-Urology @ Institute of Child Health, University College London, London (UK) Subgroup(s): [Glycans in development and physiology
]
Research interests: Dr. Winyard's group is interested in the role(s) of galectin-3 in kidney development and renal diseases, such as polycystic kidney disease (PKD).
Chi-Huey
Wong , Ph.D.[Associated Requests/Data] Professor,
Dept of Chemistry and the Skaggs Institute for Chemical Biology @ The Scripps Research Institute, La Jolla, CA (USA) Subgroup(s): [Glycans in immune recognition and function
, Glycan synthesis and microarrays
, Glycans in cancer biology]
Research interests: Dr. Wong's laboratory is interested in new chemistry for the synthesis of oligosaccharides, aminoglycosides, glycolipids and glycoproteins; design, synthesis and bioactivity evaluation of carbohydrate mimetics and glycosyltransfer enzymes inhibitors; automated programmable one-pot oligosaccharide synthesis; development of glycoarrays for high throughput analysis; glycosyltransferases and sulfotransferases: mechanism, inhibition and synthetic application; aldolases: mechanism, directed evolution and synthetic application; carbohydrate-based vaccines; structures of glycosyltransferases, sulfotransferases, aldolases, and CD-1/T-cell complexed with ligands (with Ian Wilson).
Henry H.
Wortis , M.D. Professor and Chair,
Department of Pathology/Immunology @ Tufts University School of Medicine, Boston, MA (USA) Subgroup(s): [Glycans in development and physiology
, Glycans in immune recognition and function
]
Research interests: This laboratory is interested in understanding how the B cell negative regulator CD22 serves to prevent the development of autoimmunity. Currently, the lab is studying how the lectin function of this molecule serves its regulatory functions. The lab is also interested in characterizing the essential molecules along the pathway.
Hui
Wu , Ph.D.[Associated Requests/Data] Assistant Professor,
Pediatric Dentistry & Microbiology @ University of Alabama at Birmingham, AL (USA) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory focuses on identification and characterization of glycan binding activities of a bacterial virulent factor and its host partner
Mingdi
Yan , Ph.D. Associate Professor,
Dept of Chemistry @ Portland State University, OR (USA) Subgroup(s): [Glycan synthesis and microarrays
]
Research interests: This laboratory focuses in developing new approaches to construct carbohydrate microarrays.
Kevin
Yarema , Ph.D.[Associated Requests/Data] Assistant Professor,
Department of Biomedical Engineering @ The Johns Hopkins University, Baltimore, MD (USA) Subgroup(s): [Structural glycobiology, Glycans in cancer biology, Glycans in development and physiology
, Glycomics and glycoinformatics]
Research interests: This laboratory is focuses on the study of sialic acid metabolism and how perturbations to the biosynthesis of this sugar impact cells from two perspectives. The first is to determine how genetic abnormalites to sialic acid-processing enzymes found in human diseases result in large-scale cellular abnormalities. The second is to use non-natural intermediates of the sialic acid pathway, which are biosynthetically incorporated into cellular glycans, to metabolically engineer new properties into cells
Bang-Ce
Ye , Ph.D.[Associated Requests/Data] Associate Professor,
State Key Laboratory of Bioreactor Engineering, College of Biotechnology @ East China University of Science & Technology, Shanghai (China) Subgroup(s): [Glycan synthesis and microarrays
]
Research interests: This laboratory focuses in constructing the chemical microarrays for high throughput screening of inhibitors of enzymes from TCM (Traditional Chinese Medicine).
Ho Sup
Yoon , Ph.D.[Associated Requests/Data] Associate Professor,
Division of Chemical Biology & BioTechnology, School of Biological Sciences, Nanyang Technological University (Singapore) Subgroup(s): [To be Assigned]
Research interests: This laboratory is focused on lectins from one of the local mistletoe species Viscum ovalifolium and investigated their biological effects
William S.
York , Ph.D. Associate Professor,
Complex Carbohydrate Research Center, Department of Biochemistry and Molecular Biology @ University of Georgia, Athens, GA (USA) Subgroup(s): [Glycomics and glycoinformatics]
Research interests: Dr. York's research, in collaboration with scientists at the Large Scale Distributed Information Systems laboratory at the University of Georgia, focuses on the development of open data formats, semantic analysis, and data mining techniques to explore glycomics data from diverse sources.
Xinping
Yue , M.D., Ph.D. [Associated Requests/Data] Assistant Professor,
Department of Physiology @ Louisiana State University Health Sciences Center, New Orleans, LA (USA) Subgroup(s): [Glycans in development and physiology
]
Research interests: This laboratory is focused on the role of heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, in the development of pulmonary fibrosis
Yong-Lian
Zhang , Ph.D.[Associated Requests/Data] Professor,
Laboratory of Molecular Biology @ Shanghai Institute for Biological Sciences (China) Subgroup(s): [Glycans in development and physiology
, Structural glycobiology]
Research interests: This laboratory studies sperm maturation related epididymis-specific programmatically expressed novel genes, and how the modifications of sperm surface proteins by interacting with epididymal proteins makes the sperm acquire its individual functions.
Jian
Zhang , Ph.D.[Associated Requests/Data] Founder,
Z Biotech Subgroup(s): [Glycan synthesis and microarrays
]
Research interests: Z Biotech is a designer and service provider of glycan analysis tools. As a leader in cost-effective biochemical solutions, our focus is to develop innovative glycan microarray and carbohydrate products and related services.
Guangming
Zhong , M.D., Ph.D. Professor,
Department of Microbiology and Immunology @ University of Texas Health Science Center at San Antonio, TX (USA) Subgroup(s): [Glycans in host-microbe interactions]
Research interests: This laboratory is focus on chlamydial interactions with host cells and chlamydial vaccine development.
Dapeng
Zhou , M.D.,[Associated Requests/Data] Assistant Professor,
Department of Melanoma Medical Oncology @ University of Texas M.D. Anderson Cancer Center, Texas (USA) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This laboratory studies the T cell recognition of glycolipid antigens, including the biochemical characterization of glycolipid antigens, the cell biology of glycolipid antigen presenting machinery, the chemical synthesis of self and foreign glycolipids, and the cellular immunology that might shed light on finding glycolipid targets for adjuvant and vaccine development.
Hermann
Ziltener , Ph.D. Professor,
The Biomedical Research Centre and Department of Pathology & Laboratory Medicine @ University of British Columbia, Vancouver British Columbia (Canada) Subgroup(s): [Glycans in immune recognition and function
]
Research interests: This group is focused on 1) the mechanisms that control the activities of glycosyltransferases that lead to formation of selectin ligands and 2) cell biology of C2 GlcNAcT enzymes.
Emmanuel
Zorn , Ph.D.[Associated Requests/Data] Assistant Professor of Surgery,
Massachusetts General Hospital Subgroup(s): [Glycans in immune recognition and function
]
Research interests: Glycobiology of human transplantation and to understand how human antibodies can recognize distinct glycans at the surface of donor cells in transplanted organs and contribute to graft rejection.
